119166

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 473790..475273 Replicon chromosome
Accession NZ_CP036026
Organism Bacillus mycoides strain BPN54/2

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag EXW38_RS02525 Protein ID WP_215572348.1
Coordinates 473790..474521 (+) Length 244 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag EXW38_RS02530 Protein ID WP_215572349.1
Coordinates 474524..475273 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW38_RS02460 468986..469123 + 138 WP_215572340.1 hypothetical protein -
EXW38_RS02465 (EXW38_02490) 469166..469513 + 348 WP_235713374.1 hypothetical protein -
EXW38_RS02470 (EXW38_02495) 469689..469991 + 303 WP_088099820.1 hypothetical protein -
EXW38_RS02475 (EXW38_02500) 470272..470535 + 264 WP_215572341.1 hypothetical protein -
EXW38_RS02480 (EXW38_02505) 470783..470977 + 195 WP_215572342.1 hypothetical protein -
EXW38_RS02485 (EXW38_02510) 471014..471376 + 363 WP_215572974.1 hypothetical protein -
EXW38_RS02490 471406..471564 + 159 WP_215572343.1 hypothetical protein -
EXW38_RS02495 (EXW38_02515) 471645..471854 + 210 WP_215572344.1 hypothetical protein -
EXW38_RS02500 (EXW38_02520) 471899..472021 + 123 WP_215572345.1 DUF3983 domain-containing protein -
EXW38_RS02505 (EXW38_02525) 472042..472224 + 183 WP_215572346.1 hypothetical protein -
EXW38_RS02510 472336..472506 + 171 WP_083596019.1 hypothetical protein -
EXW38_RS02515 (EXW38_02530) 472534..473016 + 483 WP_215572347.1 ArpU family phage packaging/lysis transcriptional regulator -
EXW38_RS02520 (EXW38_02535) 473016..473558 + 543 WP_002010102.1 site-specific integrase -
EXW38_RS02525 (EXW38_02540) 473790..474521 + 732 WP_215572348.1 hypothetical protein Toxin
EXW38_RS02530 (EXW38_02545) 474524..475273 + 750 WP_215572349.1 DUF4065 domain-containing protein Antitoxin
EXW38_RS02535 (EXW38_02550) 475727..476011 + 285 WP_215572915.1 hypothetical protein -
EXW38_RS02540 (EXW38_02555) 476094..476390 + 297 WP_215572975.1 hypothetical protein -
EXW38_RS02545 (EXW38_02560) 476353..476577 + 225 WP_235713375.1 helix-turn-helix domain-containing protein -
EXW38_RS02550 (EXW38_02565) 476565..476891 + 327 WP_215572351.1 HNH endonuclease -
EXW38_RS02555 (EXW38_02570) 476951..477196 + 246 WP_215572916.1 hypothetical protein -
EXW38_RS02560 (EXW38_02575) 477498..477998 + 501 WP_215572352.1 P27 family phage terminase small subunit -
EXW38_RS02565 (EXW38_02580) 477982..479640 + 1659 WP_215572353.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 456572..496953 40381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(108-219)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 244 a.a.        Molecular weight: 29216.09 Da        Isoelectric Point: 7.4273

>T119166 WP_215572348.1 NZ_CP036026:473790-474521 [Bacillus mycoides]
MESLQLQSLRETKPYCYYNEIQQIIIEICHFHNEFSAAWIKKNQSSELEFLNFNRKQVRQVTDIIEEREVFFLKDKFNSL
IKSYMNELKPLTIDFEMEYKYENFDFRSRGKQFDSIMNKLKYYRVGKQGNGVFGAFNLNKCLNDLFGIRIVIEDFDHNCK
SFYQLCEEMRTKHRIRVMDSSKHGYKATHIYFHGESNQYFPWELQIWNTDDCKSNDISHGIHKRAYTEWASIYKNSKEIE
GGA

Download         Length: 732 bp

>T119166 NZ_CP036026:473790-474521 [Bacillus mycoides]
TTGGAAAGCTTACAATTACAAAGTTTACGAGAAACTAAACCATATTGTTATTATAACGAGATACAGCAGATTATCATTGA
AATTTGTCATTTTCATAATGAATTCTCAGCAGCGTGGATAAAAAAGAATCAGTCAAGCGAATTAGAATTTCTAAACTTTA
ATAGGAAACAAGTTAGACAAGTGACTGATATTATTGAAGAAAGAGAAGTATTCTTTCTGAAGGATAAATTTAATAGTCTA
ATAAAAAGCTATATGAACGAATTAAAGCCTTTAACAATAGATTTCGAGATGGAATATAAATATGAAAACTTTGATTTTCG
ATCTCGTGGAAAACAATTTGATTCAATAATGAATAAATTAAAATATTACAGAGTTGGAAAACAAGGAAATGGAGTTTTTG
GAGCTTTTAACCTCAATAAATGTTTAAACGATCTTTTCGGTATTCGAATAGTGATTGAAGATTTTGACCATAATTGTAAG
AGTTTTTATCAATTATGTGAAGAAATGAGAACTAAACATAGAATACGTGTAATGGATTCGTCAAAGCATGGTTATAAAGC
GACTCATATATATTTTCATGGGGAAAGTAATCAGTATTTTCCTTGGGAGTTACAAATATGGAATACAGATGATTGTAAAT
CAAATGACATTTCACATGGGATACATAAACGCGCATATACTGAATGGGCATCAATTTATAAGAATTCAAAAGAAATTGAG
GGAGGTGCTTAA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28151.96 Da        Isoelectric Point: 6.2719

>AT119166 WP_215572349.1 NZ_CP036026:474524-475273 [Bacillus mycoides]
MAFHFIAIMSHYSHGGRIAWHYSAETRLDKEFIQSFFSRVERKCGEVQLGIHKLSTESTSWDSVVQKDSFFKDVYRTQDI
DTFIGMVVQDQELSPTDVSKFILSISPSSHLKLQKLLYFSYAEFLLQTGVKLFKEPLVAFKYGPVVESVFHKYKVHGSTV
IDSREDETICYSTESLAITPSIMKVASSEHGDSAIACILNVLEKYGGYSAGDLVDKTHQAGGPWDRVFKPGSNCEITDDL
IIQYHQVIQ

Download         Length: 750 bp

>AT119166 NZ_CP036026:474524-475273 [Bacillus mycoides]
ATGGCTTTTCACTTTATTGCAATTATGAGTCACTATTCGCACGGGGGACGAATCGCATGGCATTATTCTGCCGAAACTCG
ACTTGATAAAGAATTCATCCAAAGTTTTTTTAGTCGAGTAGAAAGAAAATGTGGAGAAGTACAATTAGGTATCCACAAAT
TATCGACAGAGTCTACTAGTTGGGATTCTGTAGTACAAAAGGATTCTTTCTTTAAAGATGTATATAGAACTCAGGATATC
GATACTTTTATTGGAATGGTTGTTCAGGATCAGGAATTAAGTCCTACAGATGTTTCAAAGTTTATACTATCAATTTCACC
ATCTTCACATCTTAAATTACAAAAATTACTTTATTTTTCATATGCAGAATTCTTATTACAAACAGGCGTTAAATTATTTA
AAGAACCATTAGTAGCCTTTAAATATGGACCTGTAGTTGAAAGTGTTTTTCATAAGTATAAAGTTCATGGCTCTACAGTA
ATTGATTCTAGAGAAGATGAGACAATTTGTTATTCAACAGAATCATTAGCTATTACACCTTCTATTATGAAAGTGGCATC
TTCAGAACATGGTGATTCGGCAATAGCGTGTATTTTAAATGTATTAGAAAAGTACGGTGGATATAGCGCGGGAGATTTAG
TTGATAAGACACATCAAGCAGGTGGTCCTTGGGATAGAGTGTTTAAGCCAGGGTCTAATTGTGAAATTACTGATGATTTA
ATTATACAGTATCATCAGGTGATTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References