119163

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2371990..2372968 Replicon chromosome
Accession NZ_CP036023
Organism Bacillus mycoides strain BPN52/2

Toxin (Protein)


Gene name spoIISA Uniprot ID R8N1U0
Locus tag EXW49_RS11955 Protein ID WP_002032139.1
Coordinates 2371990..2372730 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW49_RS11960 Protein ID WP_000588712.1
Coordinates 2372843..2372968 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW49_RS11925 (EXW49_12160) 2367092..2367853 + 762 WP_016102007.1 ABC transporter ATP-binding protein -
EXW49_RS11930 (EXW49_12165) 2367959..2368669 + 711 WP_215589028.1 class I SAM-dependent methyltransferase -
EXW49_RS11935 (EXW49_12170) 2368788..2369201 + 414 WP_002012925.1 VOC family protein -
EXW49_RS11940 (EXW49_12175) 2369378..2370010 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW49_RS11945 (EXW49_12180) 2370284..2370760 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW49_RS11950 (EXW49_12185) 2370914..2371651 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW49_RS11955 (EXW49_12190) 2371990..2372730 + 741 WP_002032139.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW49_RS11960 (EXW49_12195) 2372843..2372968 + 126 WP_000588712.1 hypothetical protein Antitoxin
EXW49_RS11965 2373044..2373220 + 177 WP_002017052.1 stage II sporulation protein SB -
EXW49_RS11970 (EXW49_12200) 2373240..2373629 - 390 WP_215589029.1 YxeA family protein -
EXW49_RS11975 (EXW49_12205) 2373881..2375350 + 1470 WP_215589030.1 aminoacyl-histidine dipeptidase -
EXW49_RS11980 2375710..2375859 + 150 WP_002069316.1 hypothetical protein -
EXW49_RS11985 (EXW49_12210) 2376615..2377274 + 660 WP_061675943.1 CatB-related O-acetyltransferase -
EXW49_RS29565 2377469..2377617 + 149 Protein_2291 bacitracin ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28482.11 Da        Isoelectric Point: 8.3034

>T119163 WP_002032139.1 NZ_CP036023:2371990-2372730 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119163 NZ_CP036023:2371990-2372730 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119163 WP_000588712.1 NZ_CP036023:2372843-2372968 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119163 NZ_CP036023:2372843-2372968 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8N1U0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References