Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2363337..2364315 Replicon chromosome
Accession NZ_CP036017
Organism Bacillus mycoides strain BPN51/1

Toxin (Protein)


Gene name spoIISA Uniprot ID R8N1U0
Locus tag EXW52_RS12095 Protein ID WP_002032139.1
Coordinates 2363337..2364077 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID J8YSJ3
Locus tag EXW52_RS12100 Protein ID WP_002069312.1
Coordinates 2364190..2364315 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW52_RS12070 (EXW52_12325) 2359307..2360017 + 711 WP_061689428.1 class I SAM-dependent methyltransferase -
EXW52_RS12075 (EXW52_12330) 2360136..2360549 + 414 WP_002012925.1 VOC family protein -
EXW52_RS12080 (EXW52_12335) 2360726..2361358 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW52_RS12085 (EXW52_12340) 2361632..2362108 + 477 WP_061689429.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW52_RS12090 (EXW52_12345) 2362262..2362999 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW52_RS12095 (EXW52_12355) 2363337..2364077 + 741 WP_002032139.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW52_RS12100 (EXW52_12360) 2364190..2364315 + 126 WP_002069312.1 hypothetical protein Antitoxin
EXW52_RS12105 (EXW52_12365) 2364391..2364567 + 177 WP_002141782.1 stage II sporulation protein SB -
EXW52_RS12110 (EXW52_12370) 2364611..2364886 - 276 WP_002141783.1 hypothetical protein -
EXW52_RS12115 (EXW52_12375) 2364913..2365443 - 531 WP_040963068.1 hypothetical protein -
EXW52_RS12120 2365765..2365941 + 177 WP_002141786.1 stage II sporulation protein SB -
EXW52_RS12125 (EXW52_12380) 2366017..2366406 - 390 WP_061689430.1 YxeA family protein -
EXW52_RS12130 (EXW52_12385) 2366658..2368127 + 1470 WP_016102002.1 aminoacyl-histidine dipeptidase -
EXW52_RS12135 2368487..2368636 + 150 WP_187770547.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28482.11 Da        Isoelectric Point: 8.3034

>T119161 WP_002032139.1 NZ_CP036017:2363337-2364077 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119161 NZ_CP036017:2363337-2364077 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ACGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4937.36 Da        Isoelectric Point: 3.9798

>AT119161 WP_002069312.1 NZ_CP036017:2364190-2364315 [Bacillus mycoides]
VIKDYDNDFFKENNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119161 NZ_CP036017:2364190-2364315 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAAATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8N1U0

Antitoxin

Source ID Structure
AlphaFold DB J8YSJ3

References