Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2360171..2361149 | Replicon | chromosome |
| Accession | NZ_CP036009 | ||
| Organism | Bacillus mycoides strain BPN43/2 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | EXW40_RS12075 | Protein ID | WP_215587813.1 |
| Coordinates | 2360171..2360911 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | EXW40_RS12080 | Protein ID | WP_000588712.1 |
| Coordinates | 2361024..2361149 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW40_RS12050 (EXW40_12260) | 2355868..2356629 | + | 762 | WP_215587809.1 | ABC transporter ATP-binding protein | - |
| EXW40_RS12055 (EXW40_12265) | 2356736..2357446 | + | 711 | WP_215587810.1 | class I SAM-dependent methyltransferase | - |
| EXW40_RS12060 (EXW40_12270) | 2357566..2357979 | + | 414 | WP_215587811.1 | VOC family protein | - |
| EXW40_RS12065 (EXW40_12275) | 2358464..2358940 | + | 477 | WP_002017049.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW40_RS12070 (EXW40_12280) | 2359094..2359831 | + | 738 | WP_215587812.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW40_RS29365 | 2359930..2360070 | - | 141 | WP_235702278.1 | spermidine/putrescine ABC transporter ATP-binding protein | - |
| EXW40_RS12075 (EXW40_12285) | 2360171..2360911 | + | 741 | WP_215587813.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW40_RS12080 (EXW40_12290) | 2361024..2361149 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| EXW40_RS12085 | 2361225..2361401 | + | 177 | WP_172798766.1 | stage II sporulation protein SB | - |
| EXW40_RS12090 (EXW40_12295) | 2361421..2361810 | - | 390 | WP_033733970.1 | YxeA family protein | - |
| EXW40_RS12095 (EXW40_12300) | 2362063..2363532 | + | 1470 | WP_016102002.1 | aminoacyl-histidine dipeptidase | - |
| EXW40_RS12100 | 2363892..2364041 | + | 150 | WP_002069316.1 | hypothetical protein | - |
| EXW40_RS12105 (EXW40_12305) | 2364792..2365451 | + | 660 | WP_215587814.1 | CatB-related O-acetyltransferase | - |
| EXW40_RS29370 (EXW40_12310) | 2365646..2365794 | + | 149 | Protein_2315 | bacitracin ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28526.23 Da Isoelectric Point: 8.3034
>T119153 WP_215587813.1 NZ_CP036009:2360171-2360911 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIMVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFIK
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIMVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFIK
Download Length: 741 bp
>T119153 NZ_CP036009:2360171-2360911 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGGGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATGGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTATTAAATGA
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGGGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATGGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTATTAAATGA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT119153 WP_000588712.1 NZ_CP036009:2361024-2361149 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT119153 NZ_CP036009:2361024-2361149 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|