Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 4534871..4536354 Replicon chromosome
Accession NZ_CP035999
Organism Bacillus mycoides strain BPN37/1

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag EXW27_RS23455 Protein ID WP_078177836.1
Coordinates 4534871..4535602 (+) Length 244 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag EXW27_RS23460 Protein ID WP_078177837.1
Coordinates 4535605..4536354 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW27_RS23410 (EXW27_23815) 4530822..4531187 + 366 WP_147740045.1 hypothetical protein -
EXW27_RS23415 (EXW27_23820) 4531224..4531589 + 366 WP_147740044.1 YopX family protein -
EXW27_RS31265 4531640..4532248 + 609 WP_235712288.1 hypothetical protein -
EXW27_RS23425 4532601..4532765 - 165 WP_088122214.1 hypothetical protein -
EXW27_RS23430 4532893..4533066 + 174 WP_179957889.1 hypothetical protein -
EXW27_RS23435 (EXW27_23835) 4533085..4533207 + 123 WP_002010097.1 DUF3983 domain-containing protein -
EXW27_RS23440 4533321..4533491 + 171 WP_215598701.1 hypothetical protein -
EXW27_RS23445 (EXW27_23840) 4533519..4534001 + 483 WP_078204473.1 ArpU family phage packaging/lysis transcriptional regulator -
EXW27_RS23450 (EXW27_23845) 4534001..4534543 + 543 WP_002010102.1 site-specific integrase -
EXW27_RS23455 (EXW27_23850) 4534871..4535602 + 732 WP_078177836.1 hypothetical protein Toxin
EXW27_RS23460 (EXW27_23855) 4535605..4536354 + 750 WP_078177837.1 DUF4065 domain-containing protein Antitoxin
EXW27_RS23465 (EXW27_23860) 4536915..4537589 + 675 WP_078177838.1 hypothetical protein -
EXW27_RS23470 4537749..4537886 + 138 WP_158080629.1 hypothetical protein -
EXW27_RS23475 (EXW27_23865) 4538023..4538358 + 336 WP_078177839.1 HNH endonuclease -
EXW27_RS23480 (EXW27_23870) 4538483..4538794 + 312 WP_088291085.1 P27 family phage terminase small subunit -
EXW27_RS23485 (EXW27_23875) 4538791..4540458 + 1668 WP_147740025.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4518490..4586152 67662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(111-221)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 244 a.a.        Molecular weight: 28912.62 Da        Isoelectric Point: 5.6744

>T119149 WP_078177836.1 NZ_CP035999:4534871-4535602 [Bacillus mycoides]
MDILQIQGLQDLQEIKPYCHYSDIQKLFLEIYDLHNKFSAAWIKKNQTTGFEFMNLNKRQVRNVSSVIEDREVFLIDNMF
YRLIKSYMNELESLTVESELEYDYTELDLRTRIKQNESVVNKLKYYRVGKEGAGAFNLNKCLNDLFGIRIIIEDFDHNCR
YFNDLCEGLKAEYRIRTMDSSKNNYKATHIYFYGESNRYFPWELQVWNANDLSSNVISHSLHKQEYTKWADIYKNSAEIE
GGA

Download         Length: 732 bp

>T119149 NZ_CP035999:4534871-4535602 [Bacillus mycoides]
TTGGATATTCTACAAATACAAGGTTTACAAGATTTACAAGAAATCAAGCCATATTGTCATTATAGTGATATACAAAAACT
TTTTTTAGAAATTTATGATCTACATAATAAATTCTCAGCAGCATGGATTAAAAAAAATCAGACAACCGGATTCGAATTCA
TGAATTTAAATAAGAGACAGGTTAGAAATGTTTCAAGTGTTATTGAGGATAGAGAAGTATTTTTAATTGACAATATGTTT
TATCGTCTTATTAAAAGTTATATGAATGAATTGGAATCATTGACGGTGGAGAGTGAATTAGAATACGATTATACGGAGTT
AGATCTTCGAACTCGCATAAAACAAAATGAATCCGTAGTGAATAAATTAAAGTATTATAGAGTTGGAAAAGAAGGAGCAG
GGGCTTTTAATCTAAATAAATGTTTAAATGATCTTTTTGGCATTCGAATAATTATTGAAGATTTTGACCATAACTGTAGA
TACTTTAACGATTTATGTGAAGGCTTAAAGGCTGAATATAGAATACGTACTATGGACTCATCAAAGAATAATTATAAAGC
TACACACATATATTTTTATGGAGAAAGTAACAGATATTTTCCTTGGGAACTACAAGTGTGGAATGCAAATGATCTCAGTT
CAAATGTTATATCGCACTCTTTACATAAACAGGAATATACAAAATGGGCTGATATTTATAAAAATTCAGCAGAAATTGAG
GGAGGTGCTTAA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28577.62 Da        Isoelectric Point: 6.1683

>AT119149 WP_078177837.1 NZ_CP035999:4535605-4536354 [Bacillus mycoides]
MAFHFIAVMSHYSDGRRIAWHYSDESKLDKEIIQGFLKRVRKKCGEVQLGIHKLATDSTTWDSVLQKDSFFKDVYKTRDV
ETFIEMIIQDQELSATDVSKFILSVLPSSHLKLQKLLYFSYAEFLLRTGAKLFKEPIVAFKYGPVVESVFHNYKVHGSTT
IDYKEDETICYSTEDLAITPSFMKLVSSEHGIVALECILKTLNQYGEVSAGDLVEKTHQDGGPWDRVFKPGWNCEITDDV
ITQYHQVIN

Download         Length: 750 bp

>AT119149 NZ_CP035999:4535605-4536354 [Bacillus mycoides]
ATGGCTTTTCACTTTATTGCAGTTATGAGTCACTATTCTGACGGGAGACGAATCGCTTGGCATTATTCCGATGAATCTAA
ACTTGATAAAGAAATTATTCAAGGTTTTTTAAAAAGAGTAAGAAAAAAATGTGGAGAAGTACAATTAGGTATCCACAAAT
TGGCGACAGATTCTACAACGTGGGATTCTGTATTACAAAAAGATTCGTTCTTTAAAGATGTATACAAAACTCGAGATGTA
GAGACTTTTATTGAAATGATTATTCAAGATCAGGAATTAAGCGCTACAGACGTTTCTAAGTTTATATTGTCCGTATTGCC
ATCCTCTCACCTTAAATTGCAAAAATTACTGTATTTTTCATACGCAGAGTTTTTATTGCGAACAGGAGCTAAATTATTTA
AGGAACCGATTGTAGCATTCAAGTATGGTCCAGTTGTTGAAAGTGTTTTTCATAATTATAAAGTTCATGGATCTACGACT
ATTGACTACAAGGAAGATGAAACAATATGTTATTCAACAGAGGATTTAGCCATTACACCATCTTTTATGAAGCTAGTATC
CTCAGAACACGGTATTGTAGCACTAGAGTGCATTTTAAAAACCTTGAATCAATATGGGGAAGTGAGTGCAGGTGATCTAG
TTGAAAAGACACATCAAGATGGAGGGCCATGGGATAGAGTATTTAAACCAGGCTGGAATTGTGAAATTACTGATGATGTT
ATTACACAATATCATCAAGTTATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References