Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 395246..396224 Replicon chromosome
Accession NZ_CP035997
Organism Bacillus mycoides strain BPN36/3

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW63_RS01995 Protein ID WP_201065725.1
Coordinates 395484..396224 (-) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EXW63_RS01990 Protein ID WP_215552300.1
Coordinates 395246..395371 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW63_RS28805 390599..390747 - 149 Protein_400 bacitracin ABC transporter ATP-binding protein -
EXW63_RS01965 (EXW63_02020) 390942..391601 - 660 WP_215552298.1 CatB-related O-acetyltransferase -
EXW63_RS01970 392357..392506 - 150 WP_002069316.1 hypothetical protein -
EXW63_RS01975 (EXW63_02025) 392866..394335 - 1470 WP_215552299.1 aminoacyl-histidine dipeptidase -
EXW63_RS01980 (EXW63_02030) 394606..394974 + 369 WP_215553103.1 YxeA family protein -
EXW63_RS01985 394994..395170 - 177 WP_002017052.1 stage II sporulation protein SB -
EXW63_RS01990 (EXW63_02035) 395246..395371 - 126 WP_215552300.1 D-alanyl-D-alanine carboxypeptidase Antitoxin
EXW63_RS01995 (EXW63_02040) 395484..396224 - 741 WP_201065725.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW63_RS02000 (EXW63_02045) 396542..397279 - 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW63_RS02005 (EXW63_02050) 397433..397909 - 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW63_RS02010 (EXW63_02055) 398183..398815 + 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW63_RS02015 (EXW63_02060) 398992..399405 - 414 WP_215552301.1 VOC family protein -
EXW63_RS02020 (EXW63_02065) 399525..400235 - 711 WP_215552302.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28509.14 Da        Isoelectric Point: 8.3034

>T119145 WP_201065725.1 NZ_CP035997:c396224-395484 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKNLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119145 NZ_CP035997:c396224-395484 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAACTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4939.33 Da        Isoelectric Point: 3.8705

>AT119145 WP_215552300.1 NZ_CP035997:c395371-395246 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLEQVEELEEELKRK

Download         Length: 126 bp

>AT119145 NZ_CP035997:c395371-395246 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGGAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References