Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 4398268..4399246 Replicon chromosome
Accession NZ_CP035987
Organism Bacillus mycoides strain BPN29/1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW60_RS22540 Protein ID WP_215587813.1
Coordinates 4398268..4399008 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW60_RS22545 Protein ID WP_000588712.1
Coordinates 4399121..4399246 (+) Length 42 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW60_RS22515 (EXW60_22965) 4393965..4394726 + 762 WP_215587809.1 ABC transporter ATP-binding protein -
EXW60_RS22520 (EXW60_22970) 4394833..4395543 + 711 WP_215598577.1 class I SAM-dependent methyltransferase -
EXW60_RS22525 (EXW60_22975) 4395663..4396076 + 414 WP_215587811.1 VOC family protein -
EXW60_RS22530 (EXW60_22980) 4396561..4397037 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW60_RS22535 (EXW60_22985) 4397191..4397928 + 738 WP_215587812.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW60_RS29225 4398027..4398167 - 141 WP_235702278.1 spermidine/putrescine ABC transporter ATP-binding protein -
EXW60_RS22540 (EXW60_22990) 4398268..4399008 + 741 WP_215587813.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW60_RS22545 (EXW60_22995) 4399121..4399246 + 126 WP_000588712.1 hypothetical protein Antitoxin
EXW60_RS22550 4399322..4399474 + 153 WP_215598578.1 hypothetical protein -
EXW60_RS22555 (EXW60_23000) 4399520..4399909 - 390 WP_033733970.1 YxeA family protein -
EXW60_RS22560 (EXW60_23005) 4400162..4401631 + 1470 WP_016102002.1 aminoacyl-histidine dipeptidase -
EXW60_RS22565 4401991..4402140 + 150 WP_002069316.1 hypothetical protein -
EXW60_RS22570 (EXW60_23010) 4402891..4403550 + 660 WP_215587814.1 CatB-related O-acetyltransferase -
EXW60_RS29230 (EXW60_23015) 4403745..4403893 + 149 Protein_4385 bacitracin ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-244)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 247 a.a.        Molecular weight: 28526.23 Da        Isoelectric Point: 8.3034

>T119141 WP_215587813.1 NZ_CP035987:4398268-4399008 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIMVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFIK

Download         Length: 741 bp

>T119141 NZ_CP035987:4398268-4399008 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGGGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATGGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTATTAAATGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119141 WP_000588712.1 NZ_CP035987:4399121-4399246 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119141 NZ_CP035987:4399121-4399246 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References