Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2397738..2398716 Replicon chromosome
Accession NZ_CP035984
Organism Bacillus mycoides strain BPN211

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW26_RS12180 Protein ID WP_201065725.1
Coordinates 2397738..2398478 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EXW26_RS12185 Protein ID WP_215552300.1
Coordinates 2398591..2398716 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW26_RS12155 (EXW26_12410) 2393727..2394437 + 711 WP_215552302.1 class I SAM-dependent methyltransferase -
EXW26_RS12160 (EXW26_12415) 2394557..2394970 + 414 WP_215552301.1 VOC family protein -
EXW26_RS12165 (EXW26_12420) 2395147..2395779 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW26_RS12170 (EXW26_12425) 2396053..2396529 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW26_RS12175 (EXW26_12430) 2396683..2397420 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW26_RS12180 (EXW26_12435) 2397738..2398478 + 741 WP_201065725.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW26_RS12185 (EXW26_12440) 2398591..2398716 + 126 WP_215552300.1 D-alanyl-D-alanine carboxypeptidase Antitoxin
EXW26_RS12190 2398792..2398968 + 177 WP_002017052.1 stage II sporulation protein SB -
EXW26_RS12195 (EXW26_12445) 2398988..2399356 - 369 WP_215553103.1 YxeA family protein -
EXW26_RS12200 (EXW26_12450) 2399627..2401096 + 1470 WP_215552299.1 aminoacyl-histidine dipeptidase -
EXW26_RS12205 2401456..2401605 + 150 WP_002069316.1 hypothetical protein -
EXW26_RS12210 (EXW26_12455) 2402361..2403020 + 660 WP_215552298.1 CatB-related O-acetyltransferase -
EXW26_RS29480 2403215..2403363 + 149 Protein_2342 bacitracin ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28509.14 Da        Isoelectric Point: 8.3034

>T119139 WP_201065725.1 NZ_CP035984:2397738-2398478 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKNLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119139 NZ_CP035984:2397738-2398478 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAACTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4939.33 Da        Isoelectric Point: 3.8705

>AT119139 WP_215552300.1 NZ_CP035984:2398591-2398716 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLEQVEELEEELKRK

Download         Length: 126 bp

>AT119139 NZ_CP035984:2398591-2398716 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGGAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References