Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2370950..2371928 Replicon chromosome
Accession NZ_CP035978
Organism Bacillus mycoides strain BPN121

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW37_RS12025 Protein ID WP_215584974.1
Coordinates 2370950..2371690 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EXW37_RS12030 Protein ID WP_215552300.1
Coordinates 2371803..2371928 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW37_RS12000 (EXW37_12260) 2366939..2367649 + 711 WP_215552302.1 class I SAM-dependent methyltransferase -
EXW37_RS12005 (EXW37_12265) 2367769..2368182 + 414 WP_215552301.1 VOC family protein -
EXW37_RS12010 (EXW37_12270) 2368359..2368991 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW37_RS12015 (EXW37_12275) 2369265..2369741 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW37_RS12020 (EXW37_12280) 2369895..2370632 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW37_RS12025 (EXW37_12285) 2370950..2371690 + 741 WP_215584974.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW37_RS12030 (EXW37_12290) 2371803..2371928 + 126 WP_215552300.1 D-alanyl-D-alanine carboxypeptidase Antitoxin
EXW37_RS12035 2372004..2372180 + 177 WP_002017052.1 stage II sporulation protein SB -
EXW37_RS12040 (EXW37_12295) 2372200..2372568 - 369 WP_215585107.1 YxeA family protein -
EXW37_RS12045 (EXW37_12300) 2372839..2374308 + 1470 WP_215552299.1 aminoacyl-histidine dipeptidase -
EXW37_RS12050 2374668..2374817 + 150 WP_002069316.1 hypothetical protein -
EXW37_RS12055 (EXW37_12305) 2375573..2376232 + 660 WP_215552298.1 CatB-related O-acetyltransferase -
EXW37_RS29285 2376427..2376575 + 149 Protein_2312 bacitracin ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28495.11 Da        Isoelectric Point: 8.3034

>T119137 WP_215584974.1 NZ_CP035978:2370950-2371690 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKNLNTFLDSYGEKVGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119137 NZ_CP035978:2370950-2371690 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAACTTAAACACATTTTTAGATTCATATGGGGAAAAGGTTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4939.33 Da        Isoelectric Point: 3.8705

>AT119137 WP_215552300.1 NZ_CP035978:2371803-2371928 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLEQVEELEEELKRK

Download         Length: 126 bp

>AT119137 NZ_CP035978:2371803-2371928 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGGAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References