Detailed information of TA system TA119130

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 12554..13285
• Replicon: plasmid p107
• Accession: NZ_CP035971
• Organism: Bacillus mycoides strain BPN09/1

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: -
• Locus tag: EXW35_RS30805
• Protein ID: WP_016128092.1
• Coordinates: 12713..13285 (+)
• Length: 191 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	12554..12650 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXW35_RS30780 (7777)	7777..7986	+	210	WP_016128086.1	DUF5511 family protein	-
EXW35_RS30785 (7983)	7983..9752	+	1770	WP_215551228.1	ArdC-like ssDNA-binding domain-containing protein	-
EXW35_RS30790 (9816)	9816..10806	+	991	Protein_11	hypothetical protein	-
EXW35_RS30795 (10828)	10828..11379	+	552	WP_016128090.1	metal-dependent hydrolase	-
EXW35_RS30800 (11458)	11458..12483	+	1026	WP_098780727.1	DUF3991 and TOPRIM domain-containing protein	-
- (12554)	12554..12650	+	97	NuclAT_0	-	Antitoxin
- (12554)	12554..12650	+	97	NuclAT_0	-	Antitoxin
- (12554)	12554..12650	+	97	NuclAT_0	-	Antitoxin
- (12554)	12554..12650	+	97	NuclAT_0	-	Antitoxin
EXW35_RS30805 (12713)	12713..13285	+	573	WP_016128092.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
EXW35_RS30810 (13673)	13673..15814	+	2142	WP_103458500.1	type IA DNA topoisomerase	-
EXW35_RS30815 (15844)	15844..16287	+	444	WP_215551229.1	CPBP family intramembrane metalloprotease	-
EXW35_RS30820 (16540)	16540..17409	+	870	WP_016128096.1	hypothetical protein	-
EXW35_RS30825 (17719)	17719..17952	-	234	WP_215551230.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..107498	107498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (8-171)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 22390.65 Da
• Isoelectric Point: 9.3730

>T119130 WP_016128092.1 NZ_CP035971:12713-13285 [Bacillus mycoides]
MANKDNPKFYTISTKYIDYLRETDSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDNTEKR
IGVLLINNMIPVPEKECKEIDIAEKTAADPKYGNLMLKQYLFLKENMDRVSNKVEKIYKDVSVQGKPSQKQKFIKGVCCD
FPKLEEKCQEYKERDQARRIAYMRQMGRER

Nucleotide

• Length: 573 bp

>T119130 NZ_CP035971:12713-13285 [Bacillus mycoides]
TTGGCTAATAAAGATAATCCTAAATTTTACACTATTTCAACTAAATATATAGACTATCTAAGAGAAACAGATAGTAAAGT
ACCCTTTAATAAAGATGAACAGCATAGCAGACCGTATGTAGGCGTATTGGAAAAAATCAATGGTCATGATTATTTTGTAC
CTTTAACATCACGTAATGATAAAAATTTTAATAGTCAGGTCAGTGTAAAATTATTCGATAACGATAACACTGAGAAGCGA
ATTGGAGTTTTATTAATAAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAACGGC
GGCAGACCCTAAGTATGGTAATTTGATGTTAAAGCAGTATTTGTTTTTAAAAGAGAACATGGATAGAGTGTCTAATAAAG
TAGAAAAAATATATAAAGATGTATCTGTACAAGGGAAGCCTTCACAAAAACAGAAATTCATTAAAGGCGTTTGTTGTGAT
TTCCCTAAATTAGAAGAAAAGTGCCAAGAATATAAAGAAAGAGATCAAGCTAGAAGGATAGCATATATGCGCCAAATGGG
GCGTGAGAGATAA

Antitoxin

Nucleotide

• Length: 97 bp

>AT119130 NZ_CP035971:12554-12650 [Bacillus mycoides]
GTAGCCTTACTTTAGTAGGCGCGAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCAAAAAAA

Structures

Antitoxin