Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2398030..2399008 Replicon chromosome
Accession NZ_CP035965
Organism Bacillus mycoides strain BPN09/1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW35_RS12245 Protein ID WP_016126943.1
Coordinates 2398030..2398770 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW35_RS12250 Protein ID WP_000588712.1
Coordinates 2398883..2399008 (+) Length 42 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW35_RS12215 (EXW35_12475) 2393132..2393893 + 762 WP_002127420.1 ABC transporter ATP-binding protein -
EXW35_RS12220 (EXW35_12480) 2393999..2394709 + 711 WP_002127421.1 class I SAM-dependent methyltransferase -
EXW35_RS12225 (EXW35_12485) 2394828..2395241 + 414 WP_002012925.1 VOC family protein -
EXW35_RS12230 (EXW35_12490) 2395418..2396050 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW35_RS12235 (EXW35_12495) 2396324..2396800 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW35_RS12240 (EXW35_12500) 2396954..2397691 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW35_RS12245 (EXW35_12505) 2398030..2398770 + 741 WP_016126943.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW35_RS12250 (EXW35_12510) 2398883..2399008 + 126 WP_000588712.1 hypothetical protein Antitoxin
EXW35_RS12255 2399084..2399260 + 177 WP_003189253.1 stage II sporulation protein SB -
EXW35_RS12260 (EXW35_12515) 2399281..2399670 - 390 WP_016126944.1 YxeA family protein -
EXW35_RS12265 (EXW35_12520) 2399916..2401385 + 1470 WP_003189257.1 aminoacyl-histidine dipeptidase -
EXW35_RS12270 2401745..2401894 + 150 WP_002069316.1 hypothetical protein -
EXW35_RS12275 (EXW35_12525) 2402608..2403267 + 660 WP_003189261.1 CatB-related O-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-244)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 247 a.a.        Molecular weight: 28485.18 Da        Isoelectric Point: 8.3034

>T119129 WP_016126943.1 NZ_CP035965:2398030-2398770 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVESVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119129 NZ_CP035965:2398030-2398770 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAGTGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119129 WP_000588712.1 NZ_CP035965:2398883-2399008 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119129 NZ_CP035965:2398883-2399008 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References