Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2398030..2399008 Replicon chromosome
Accession NZ_CP035965
Organism Bacillus mycoides strain BPN09/1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW35_RS12245 Protein ID WP_016126943.1
Coordinates 2398030..2398770 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW35_RS12250 Protein ID WP_000588712.1
Coordinates 2398883..2399008 (+) Length 42 a.a.

Genomic Context

EXW35_RS12215EXW35_RS12220EXW35_RS12225EXW35_RS12235EXW35_RS12240EXW35_RS12245EXW35_RS12250EXW35_RS12255EXW35_RS12265EXW35_RS12270EXW35_RS12275EXW35_RS12230EXW35_RS12260
Location: 2393132..2393893 (762 bp)
Type: Others
Protein ID: WP_002127420.1
Location: 2393999..2394709 (711 bp)
Type: Others
Protein ID: WP_002127421.1
Location: 2394828..2395241 (414 bp)
Type: Others
Protein ID: WP_002012925.1
Location: 2396324..2396800 (477 bp)
Type: Others
Protein ID: WP_002017049.1
Location: 2396954..2397691 (738 bp)
Type: Others
Protein ID: WP_002032137.1
Location: 2398030..2398770 (741 bp)
Type: Toxin
Protein ID: WP_016126943.1
Location: 2398883..2399008 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 2399084..2399260 (177 bp)
Type: Others
Protein ID: WP_003189253.1
Location: 2399916..2401385 (1470 bp)
Type: Others
Protein ID: WP_003189257.1
Location: 2401745..2401894 (150 bp)
Type: Others
Protein ID: WP_002069316.1
Location: 2402608..2403267 (660 bp)
Type: Others
Protein ID: WP_003189261.1
Location: 2395418..2396050 (633 bp)
Type: Others
Protein ID: WP_002017047.1
Location: 2399281..2399670 (390 bp)
Type: Others
Protein ID: WP_016126944.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EXW35_RS12215 (EXW35_12475)2393132..2393893+762WP_002127420.1ABC transporter ATP-binding protein-
EXW35_RS12220 (EXW35_12480)2393999..2394709+711WP_002127421.1class I SAM-dependent methyltransferase-
EXW35_RS12225 (EXW35_12485)2394828..2395241+414WP_002012925.1VOC family protein-
EXW35_RS12230 (EXW35_12490)2395418..2396050-633WP_002017047.1type 1 glutamine amidotransferase family protein-
EXW35_RS12235 (EXW35_12495)2396324..2396800+477WP_002017049.1MarR family winged helix-turn-helix transcriptional regulator-
EXW35_RS12240 (EXW35_12500)2396954..2397691+738WP_002032137.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
EXW35_RS12245 (EXW35_12505)2398030..2398770+741WP_016126943.1type II toxin-antitoxin system SpoIISA family toxinToxin
EXW35_RS12250 (EXW35_12510)2398883..2399008+126WP_000588712.1hypothetical proteinAntitoxin
EXW35_RS122552399084..2399260+177WP_003189253.1stage II sporulation protein SB-
EXW35_RS12260 (EXW35_12515)2399281..2399670-390WP_016126944.1YxeA family protein-
EXW35_RS12265 (EXW35_12520)2399916..2401385+1470WP_003189257.1aminoacyl-histidine dipeptidase-
EXW35_RS122702401745..2401894+150WP_002069316.1hypothetical protein-
EXW35_RS12275 (EXW35_12525)2402608..2403267+660WP_003189261.1CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28485.18 Da        Isoelectric Point: 8.3034

>T119129 WP_016126943.1 NZ_CP035965:2398030-2398770 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVESVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119129 NZ_CP035965:2398030-2398770 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAGTGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119129 WP_000588712.1 NZ_CP035965:2398883-2399008 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119129 NZ_CP035965:2398883-2399008 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References