Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 246860..247502 Replicon chromosome
Accession NZ_CP035965
Organism Bacillus mycoides strain BPN09/1

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag EXW35_RS01385 Protein ID WP_000635965.1
Coordinates 247152..247502 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag EXW35_RS01380 Protein ID WP_000004570.1
Coordinates 246860..247147 (+) Length 96 a.a.

Genomic Context

EXW35_RS01355EXW35_RS01365EXW35_RS01370EXW35_RS01375EXW35_RS01380EXW35_RS01385EXW35_RS01390EXW35_RS01400EXW35_RS01360EXW35_RS01395
Location: 242175..243137 (963 bp)
Type: Others
Protein ID: WP_002009966.1
Location: 243795..244154 (360 bp)
Type: Others
Protein ID: WP_002009969.1
Location: 244311..245261 (951 bp)
Type: Others
Protein ID: WP_002091373.1
Location: 245379..246548 (1170 bp)
Type: Others
Protein ID: WP_215550752.1
Location: 246860..247147 (288 bp)
Type: Antitoxin
Protein ID: WP_000004570.1
Location: 247152..247502 (351 bp)
Type: Toxin
Protein ID: WP_000635965.1
Location: 247571..249739 (2169 bp)
Type: Others
Protein ID: WP_002029442.1
Location: 250124..250579 (456 bp)
Type: Others
Protein ID: WP_078206738.1
Location: 243130..243702 (573 bp)
Type: Others
Protein ID: WP_002167128.1
Location: 249797..249913 (117 bp)
Type: Others
Protein ID: WP_001143642.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EXW35_RS01355 (EXW35_01365)242175..243137+963WP_002009966.1UV DNA damage repair endonuclease UvsE-
EXW35_RS01360 (EXW35_01370)243130..243702-573WP_002167128.1rhomboid family intramembrane serine protease-
EXW35_RS01365 (EXW35_01375)243795..244154+360WP_002009969.1holo-ACP synthase-
EXW35_RS01370 (EXW35_01380)244311..245261+951WP_002091373.1outer membrane lipoprotein carrier protein LolA-
EXW35_RS01375 (EXW35_01385)245379..246548+1170WP_215550752.1alanine racemase-
EXW35_RS01380 (EXW35_01390)246860..247147+288WP_000004570.1antitoxin EndoAIAntitoxin
EXW35_RS01385 (EXW35_01395)247152..247502+351WP_000635965.1type II toxin-antitoxin system endoribonuclease NdoAToxin
EXW35_RS01390 (EXW35_01400)247571..249739+2169WP_002029442.1Tex family protein-
EXW35_RS01395 (EXW35_01405)249797..249913-117WP_001143642.1cortex morphogenetic protein CmpA-
EXW35_RS01400 (EXW35_01410)250124..250579+456WP_078206738.1SprT family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T119128 WP_000635965.1 NZ_CP035965:247152-247502 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T119128 NZ_CP035965:247152-247502 [Bacillus mycoides]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGGGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT119128 WP_000004570.1 NZ_CP035965:246860-247147 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT119128 NZ_CP035965:246860-247147 [Bacillus mycoides]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A366G118

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366FY90

References