Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2345062..2346035 | Replicon | chromosome |
| Accession | NZ_CP035962 | ||
| Organism | Bacillus mycoides strain BPN07/3 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | EXW30_RS12005 | Protein ID | WP_215570491.1 |
| Coordinates | 2345062..2345802 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | EXW30_RS12010 | Protein ID | WP_000588712.1 |
| Coordinates | 2345910..2346035 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW30_RS11975 (EXW30_12170) | 2340153..2340914 | + | 762 | WP_215570484.1 | ABC transporter ATP-binding protein | - |
| EXW30_RS11980 (EXW30_12175) | 2341021..2341731 | + | 711 | WP_215570486.1 | class I SAM-dependent methyltransferase | - |
| EXW30_RS11985 (EXW30_12180) | 2341851..2342264 | + | 414 | WP_215570488.1 | VOC family protein | - |
| EXW30_RS11990 (EXW30_12185) | 2342426..2343058 | - | 633 | WP_131232115.1 | type 1 glutamine amidotransferase family protein | - |
| EXW30_RS11995 (EXW30_12190) | 2343337..2343819 | + | 483 | WP_131232116.1 | helix-turn-helix domain-containing protein | - |
| EXW30_RS12000 (EXW30_12195) | 2343987..2344724 | + | 738 | WP_131232117.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW30_RS12005 (EXW30_12200) | 2345062..2345802 | + | 741 | WP_215570491.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW30_RS12010 (EXW30_12205) | 2345910..2346035 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| EXW30_RS12015 (EXW30_12210) | 2346111..2346320 | + | 210 | WP_016092597.1 | hypothetical protein | - |
| EXW30_RS12020 (EXW30_12215) | 2346281..2346556 | - | 276 | WP_131232119.1 | hypothetical protein | - |
| EXW30_RS29205 | 2346583..2347377 | - | 795 | WP_234879579.1 | hypothetical protein | - |
| EXW30_RS12030 (EXW30_12225) | 2347427..2348227 | - | 801 | WP_215570493.1 | hypothetical protein | - |
| EXW30_RS12035 (EXW30_12230) | 2348220..2348408 | - | 189 | WP_215570494.1 | WXG100 family type VII secretion target | - |
| EXW30_RS12040 | 2348730..2348906 | + | 177 | WP_002141786.1 | stage II sporulation protein SB | - |
| EXW30_RS12045 (EXW30_12235) | 2348982..2349363 | - | 382 | Protein_2308 | YxeA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28436.15 Da Isoelectric Point: 8.3034
>T119127 WP_215570491.1 NZ_CP035962:2345062-2345802 [Bacillus mycoides]
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSIIVPLEHIDQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSIIVPLEHIDQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T119127 NZ_CP035962:2345062-2345802 [Bacillus mycoides]
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTTTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCAGCAGTATTCGGTACAA
TGGAATGGCATACGGAAGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCGCAATTTAGTATTATTGTTCCGTT
AGAACACATTGATCAACTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATAGTGAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTTTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTTTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCAGCAGTATTCGGTACAA
TGGAATGGCATACGGAAGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCGCAATTTAGTATTATTGTTCCGTT
AGAACACATTGATCAACTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATAGTGAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTTTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT119127 WP_000588712.1 NZ_CP035962:2345910-2346035 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT119127 NZ_CP035962:2345910-2346035 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGACAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAGCTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGACAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAGCTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|