Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2345062..2346035 Replicon chromosome
Accession NZ_CP035962
Organism Bacillus mycoides strain BPN07/3

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW30_RS12005 Protein ID WP_215570491.1
Coordinates 2345062..2345802 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW30_RS12010 Protein ID WP_000588712.1
Coordinates 2345910..2346035 (+) Length 42 a.a.

Genomic Context

EXW30_RS11975EXW30_RS11980EXW30_RS11985EXW30_RS11995EXW30_RS12000EXW30_RS12005EXW30_RS12010EXW30_RS12015EXW30_RS12040EXW30_RS11990EXW30_RS12020EXW30_RS29205EXW30_RS12030EXW30_RS12035EXW30_RS12045
Location: 2340153..2340914 (762 bp)
Type: Others
Protein ID: WP_215570484.1
Location: 2341021..2341731 (711 bp)
Type: Others
Protein ID: WP_215570486.1
Location: 2341851..2342264 (414 bp)
Type: Others
Protein ID: WP_215570488.1
Location: 2343337..2343819 (483 bp)
Type: Others
Protein ID: WP_131232116.1
Location: 2343987..2344724 (738 bp)
Type: Others
Protein ID: WP_131232117.1
Location: 2345062..2345802 (741 bp)
Type: Toxin
Protein ID: WP_215570491.1
Location: 2345910..2346035 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 2346111..2346320 (210 bp)
Type: Others
Protein ID: WP_016092597.1
Location: 2348730..2348906 (177 bp)
Type: Others
Protein ID: WP_002141786.1
Location: 2342426..2343058 (633 bp)
Type: Others
Protein ID: WP_131232115.1
Location: 2346281..2346556 (276 bp)
Type: Others
Protein ID: WP_131232119.1
Location: 2346583..2347377 (795 bp)
Type: Others
Protein ID: WP_234879579.1
Location: 2347427..2348227 (801 bp)
Type: Others
Protein ID: WP_215570493.1
Location: 2348220..2348408 (189 bp)
Type: Others
Protein ID: WP_215570494.1
Location: 2348982..2349363 (382 bp)
Type: Others
Protein ID: Protein_2308
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EXW30_RS11975 (EXW30_12170)2340153..2340914+762WP_215570484.1ABC transporter ATP-binding protein-
EXW30_RS11980 (EXW30_12175)2341021..2341731+711WP_215570486.1class I SAM-dependent methyltransferase-
EXW30_RS11985 (EXW30_12180)2341851..2342264+414WP_215570488.1VOC family protein-
EXW30_RS11990 (EXW30_12185)2342426..2343058-633WP_131232115.1type 1 glutamine amidotransferase family protein-
EXW30_RS11995 (EXW30_12190)2343337..2343819+483WP_131232116.1helix-turn-helix domain-containing protein-
EXW30_RS12000 (EXW30_12195)2343987..2344724+738WP_131232117.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
EXW30_RS12005 (EXW30_12200)2345062..2345802+741WP_215570491.1type II toxin-antitoxin system SpoIISA family toxinToxin
EXW30_RS12010 (EXW30_12205)2345910..2346035+126WP_000588712.1hypothetical proteinAntitoxin
EXW30_RS12015 (EXW30_12210)2346111..2346320+210WP_016092597.1hypothetical protein-
EXW30_RS12020 (EXW30_12215)2346281..2346556-276WP_131232119.1hypothetical protein-
EXW30_RS292052346583..2347377-795WP_234879579.1hypothetical protein-
EXW30_RS12030 (EXW30_12225)2347427..2348227-801WP_215570493.1hypothetical protein-
EXW30_RS12035 (EXW30_12230)2348220..2348408-189WP_215570494.1WXG100 family type VII secretion target-
EXW30_RS120402348730..2348906+177WP_002141786.1stage II sporulation protein SB-
EXW30_RS12045 (EXW30_12235)2348982..2349363-382Protein_2308YxeA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28436.15 Da        Isoelectric Point: 8.3034

>T119127 WP_215570491.1 NZ_CP035962:2345062-2345802 [Bacillus mycoides]
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSIIVPLEHIDQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119127 NZ_CP035962:2345062-2345802 [Bacillus mycoides]
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTTTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCAGCAGTATTCGGTACAA
TGGAATGGCATACGGAAGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCGCAATTTAGTATTATTGTTCCGTT
AGAACACATTGATCAACTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATAGTGAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTTTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119127 WP_000588712.1 NZ_CP035962:2345910-2346035 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119127 NZ_CP035962:2345910-2346035 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGACAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAGCTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References