Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2271203..2272180 | Replicon | chromosome |
| Accession | NZ_CP035953 | ||
| Organism | Bacillus mycoides strain BPN03/1 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | EXW58_RS11580 | Protein ID | WP_078182013.1 |
| Coordinates | 2271203..2271943 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | J8F078 |
| Locus tag | EXW58_RS11585 | Protein ID | WP_002109948.1 |
| Coordinates | 2272055..2272180 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW58_RS11550 (EXW58_11680) | 2266391..2267152 | + | 762 | WP_002161793.1 | ABC transporter ATP-binding protein | - |
| EXW58_RS11555 (EXW58_11685) | 2267259..2267969 | + | 711 | WP_215581720.1 | class I SAM-dependent methyltransferase | - |
| EXW58_RS11560 (EXW58_11690) | 2268088..2268501 | + | 414 | WP_016104868.1 | VOC family protein | - |
| EXW58_RS11565 (EXW58_11695) | 2268742..2269374 | - | 633 | WP_002017047.1 | type 1 glutamine amidotransferase family protein | - |
| EXW58_RS11570 (EXW58_11700) | 2269649..2270125 | + | 477 | WP_215581722.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW58_RS11575 (EXW58_11705) | 2270279..2271016 | + | 738 | WP_078182014.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW58_RS11580 (EXW58_11710) | 2271203..2271943 | + | 741 | WP_078182013.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW58_RS11585 (EXW58_11715) | 2272055..2272180 | + | 126 | WP_002109948.1 | hypothetical protein | Antitoxin |
| EXW58_RS11590 | 2272252..2272428 | + | 177 | WP_215581724.1 | stage II sporulation protein SB | - |
| EXW58_RS11595 (EXW58_11720) | 2272574..2274043 | + | 1470 | WP_215581726.1 | aminoacyl-histidine dipeptidase | - |
| EXW58_RS11600 (EXW58_11725) | 2274423..2275082 | + | 660 | WP_215581728.1 | CatB-related O-acetyltransferase | - |
| EXW58_RS11605 (EXW58_11730) | 2275572..2276276 | + | 705 | WP_144508620.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28296.82 Da Isoelectric Point: 7.3527
>T119125 WP_078182013.1 NZ_CP035953:2271203-2271943 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWKNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAAFGTMEWHTEEEYTKSLNAFLDSYGEKVGAK
IVVFEAANELNTNFRGIRSQFSITVPLEHIEQLNGQQAVQVENVGIIPAKIVNDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFCK
MTISNIRIGLFILAIVFIVLVFFYWKNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAAFGTMEWHTEEEYTKSLNAFLDSYGEKVGAK
IVVFEAANELNTNFRGIRSQFSITVPLEHIEQLNGQQAVQVENVGIIPAKIVNDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFCK
Download Length: 741 bp
>T119125 NZ_CP035953:2271203-2271943 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAAAAA
TGAAGAATTGTATGAGGAGAAGAAACAGCGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCTAACATTTCAGAAATATGGGGTGCGAAATTCAGTGATATCGGAAAGACGGTCCAATCAATTAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTAAATCCAGCAGCATTTGGGACAA
TGGAATGGCACACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTCTTGATTCGTATGGTGAAAAAGTAGGTGCGAAA
ATTGTTGTATTTGAAGCAGCGAACGAATTAAATACGAATTTCCGTGGTATTCGCTCTCAATTTAGTATTACAGTACCTCT
AGAACATATAGAGCAATTGAATGGCCAGCAAGCGGTTCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAATG
ATGTTTTTATTGTTATTGATGGGAAGAAGAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTTGTAAGTAG
TTGACGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAAAAA
TGAAGAATTGTATGAGGAGAAGAAACAGCGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCTAACATTTCAGAAATATGGGGTGCGAAATTCAGTGATATCGGAAAGACGGTCCAATCAATTAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTAAATCCAGCAGCATTTGGGACAA
TGGAATGGCACACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTCTTGATTCGTATGGTGAAAAAGTAGGTGCGAAA
ATTGTTGTATTTGAAGCAGCGAACGAATTAAATACGAATTTCCGTGGTATTCGCTCTCAATTTAGTATTACAGTACCTCT
AGAACATATAGAGCAATTGAATGGCCAGCAAGCGGTTCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAATG
ATGTTTTTATTGTTATTGATGGGAAGAAGAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTTGTAAGTAG
Antitoxin
Download Length: 42 a.a. Molecular weight: 4936.37 Da Isoelectric Point: 3.9421
>AT119125 WP_002109948.1 NZ_CP035953:2272055-2272180 [Bacillus mycoides]
VIKEYDNDFFKEENEDATDFSLIKGDTLQQVEELEEELKRK
VIKEYDNDFFKEENEDATDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT119125 NZ_CP035953:2272055-2272180 [Bacillus mycoides]
GTGATAAAAGAATATGATAATGATTTTTTTAAAGAAGAAAATGAAGATGCAACAGATTTTTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAGTGA
GTGATAAAAGAATATGATAATGATTTTTTTAAAGAAGAAAATGAAGATGCAACAGATTTTTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|