Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5488863..5489514 Replicon chromosome
Accession NZ_CP035952
Organism Pseudomonas sp. SNU WT1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EXN22_RS25265 Protein ID WP_130266580.1
Coordinates 5489332..5489514 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EXN22_RS25260 Protein ID WP_130266579.1
Coordinates 5488863..5489267 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN22_RS25250 5484891..5488634 + 3744 WP_130266578.1 bifunctional diguanylate cyclase/phosphodiesterase -
EXN22_RS25260 5488863..5489267 - 405 WP_130266579.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EXN22_RS25265 5489332..5489514 - 183 WP_130266580.1 type II toxin-antitoxin system HicA family toxin Toxin
EXN22_RS25270 5489649..5490446 - 798 WP_130266581.1 helix-turn-helix transcriptional regulator -
EXN22_RS25275 5490531..5491349 + 819 WP_130266582.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
EXN22_RS25280 5491442..5491903 + 462 WP_130266583.1 Lrp/AsnC family transcriptional regulator -
EXN22_RS25285 5492022..5492360 + 339 WP_130266584.1 toxin -
EXN22_RS25290 5492362..5492676 + 315 WP_130266585.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6685.72 Da        Isoelectric Point: 11.2655

>T119122 WP_130266580.1 NZ_CP035952:c5489514-5489332 [Pseudomonas sp. SNU WT1]
MRSREIIALLEADGWQEVGVRGSHHHFKHPTRPGRVTVPHPKSDLPKGTLNNILKTAGLK

Download         Length: 183 bp

>T119122 NZ_CP035952:c5489514-5489332 [Pseudomonas sp. SNU WT1]
ATGCGAAGTAGGGAGATTATCGCGTTACTTGAGGCGGATGGATGGCAAGAGGTCGGGGTGAGAGGTAGTCACCACCACTT
CAAGCATCCAACCAGACCCGGCAGGGTGACAGTCCCGCATCCCAAGAGCGATTTACCGAAAGGGACGCTGAACAACATAT
TGAAAACCGCTGGCCTCAAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14642.41 Da        Isoelectric Point: 4.2146

>AT119122 WP_130266579.1 NZ_CP035952:c5489267-5488863 [Pseudomonas sp. SNU WT1]
MKFPVVIHKDPDSDYGVIVPDVAGCFSSGTTVEEALDNVQEALALHFESLVADEEPLPQGQAIDVHIDNPDYAGGVWAVV
DFDVTPYLGKSVRFNASLPEFLLQRIDSYVKNHPEQKSRSGFLASAALRVLQEA

Download         Length: 405 bp

>AT119122 NZ_CP035952:c5489267-5488863 [Pseudomonas sp. SNU WT1]
ATGAAATTTCCAGTCGTCATTCATAAAGACCCCGATTCAGACTATGGCGTGATTGTGCCGGATGTTGCGGGCTGCTTCTC
TTCAGGTACAACCGTCGAAGAAGCGCTGGACAATGTCCAGGAGGCTTTGGCCCTGCACTTCGAGTCACTGGTCGCCGACG
AGGAGCCACTGCCTCAGGGCCAGGCTATTGATGTCCATATCGATAATCCCGACTATGCGGGCGGTGTGTGGGCAGTCGTT
GATTTTGATGTGACGCCGTACTTGGGCAAGTCAGTGCGGTTCAATGCGTCTCTGCCGGAGTTCCTGCTGCAGCGCATCGA
TAGCTATGTAAAGAATCATCCCGAACAGAAAAGCCGATCGGGTTTTCTGGCATCAGCTGCGCTTCGAGTCTTACAGGAGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References