Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4010059..4011271 Replicon chromosome
Accession NZ_CP035952
Organism Pseudomonas sp. SNU WT1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EXN22_RS18280 Protein ID WP_130265391.1
Coordinates 4010702..4011271 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EXN22_RS18275 Protein ID WP_130265390.1
Coordinates 4010059..4010616 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN22_RS18255 4005700..4006344 + 645 WP_130265386.1 nicotinamidase -
EXN22_RS18260 4006347..4007552 + 1206 WP_130265387.1 nicotinate phosphoribosyltransferase -
EXN22_RS18265 4007564..4008421 + 858 WP_130265388.1 ammonia-dependent NAD(+) synthetase -
EXN22_RS18270 4008443..4009831 + 1389 WP_130265389.1 hypothetical protein -
EXN22_RS18275 4010059..4010616 + 558 WP_130265390.1 helix-turn-helix domain-containing protein Antitoxin
EXN22_RS18280 4010702..4011271 + 570 WP_130265391.1 HD domain-containing protein Toxin
EXN22_RS18285 4011354..4011833 + 480 WP_115086215.1 hypothetical protein -
EXN22_RS18290 4011846..4012088 + 243 WP_130265392.1 hypothetical protein -
EXN22_RS18295 4012222..4012707 + 486 WP_130265393.1 hypothetical protein -
EXN22_RS18300 4012715..4012957 + 243 WP_130265394.1 hypothetical protein -
EXN22_RS18305 4012967..4013209 + 243 WP_130265395.1 hypothetical protein -
EXN22_RS18310 4013437..4015044 + 1608 WP_130265396.1 ATP-binding cassette domain-containing protein -
EXN22_RS18315 4015021..4015551 - 531 WP_130265397.1 cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-182)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-58)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21070.77 Da        Isoelectric Point: 4.7221

>T119121 WP_130265391.1 NZ_CP035952:4010702-4011271 [Pseudomonas sp. SNU WT1]
MSSTLTGRLAFLREAEKLKDVLRSAHTSSGRTESTAEHSWRLCLMAIVFADQLPALDMLKVLKLCVIHDLGEALHGDIPA
VSQAAHPDKSEQERADLLELTRSLDPGLQSEILALWEEYEHASSDEALAVKALDKLETLLQHTQGANPADFDYTFNLDYG
RKYTSTNPLFQALRALIDEDTRRLVANEP

Download         Length: 570 bp

>T119121 NZ_CP035952:4010702-4011271 [Pseudomonas sp. SNU WT1]
ATGAGCAGCACTCTCACGGGCCGCCTGGCATTCCTGCGCGAGGCCGAGAAACTCAAGGATGTACTGCGCAGTGCCCACAC
CTCCAGTGGCCGCACCGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCCATCGTCTTTGCCGACCAGTTGC
CGGCGCTGGATATGCTCAAGGTCCTCAAGCTCTGCGTCATTCACGACCTGGGCGAAGCCCTGCACGGCGACATCCCGGCG
GTCAGCCAGGCGGCCCATCCAGACAAGAGCGAGCAGGAACGCGCCGACCTGCTGGAGCTGACCCGCTCGCTGGATCCTGG
GCTGCAAAGCGAGATCCTGGCCTTGTGGGAAGAATACGAACACGCCAGCAGCGACGAAGCCTTGGCGGTCAAGGCGCTCG
ATAAACTCGAAACCCTGCTGCAACACACCCAGGGCGCCAACCCGGCCGACTTCGACTACACCTTCAATCTCGATTACGGG
CGCAAGTACACCAGCACCAACCCGCTGTTCCAGGCCCTGCGCGCACTGATCGACGAAGATACTCGCCGCCTGGTCGCCAA
TGAGCCGTAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20305.38 Da        Isoelectric Point: 8.9404

>AT119121 WP_130265390.1 NZ_CP035952:4010059-4010616 [Pseudomonas sp. SNU WT1]
MLDTPLKPAQLGVALRRWRLLNRIKQAHAAQLFGVAQSTVSRWENGSQAMEPSERVLIETRLAARLDAPAEQALARLVSD
SPRPVHLVCDLSHRLLACSPARAAQFSIPLSQLLGRSLWRYCSAEIVNKEAALDSLGWREVLAPSAVEFSSGSNDSLIVP
ITQSLCRWTRITLSDGSAARLVETL

Download         Length: 558 bp

>AT119121 NZ_CP035952:4010059-4010616 [Pseudomonas sp. SNU WT1]
ATGCTCGACACTCCACTCAAACCCGCCCAACTCGGCGTCGCCCTGCGACGCTGGCGCCTGCTGAACCGCATCAAGCAGGC
CCATGCCGCGCAGCTGTTTGGCGTGGCGCAGTCAACCGTCTCGCGCTGGGAAAACGGCAGCCAGGCCATGGAGCCCAGCG
AACGCGTGCTGATCGAAACCCGGCTCGCCGCACGCCTTGACGCCCCCGCCGAGCAGGCCCTGGCCCGCCTGGTCAGCGAC
AGCCCGCGCCCCGTGCACCTGGTCTGCGACCTCAGTCACCGCCTGCTGGCCTGTTCCCCTGCCCGCGCGGCCCAGTTCAG
CATCCCGCTGAGCCAATTGCTCGGCCGTTCCCTGTGGCGTTACTGCAGCGCAGAGATCGTCAACAAGGAAGCCGCCCTCG
ACAGCCTCGGCTGGCGCGAAGTGCTGGCACCATCGGCAGTGGAATTCTCCAGTGGCAGCAACGACTCGTTGATCGTCCCC
ATCACCCAGAGCCTGTGCCGCTGGACCCGCATCACCCTCTCCGACGGCAGCGCCGCGCGGCTGGTGGAAACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References