Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1812357..1814050 Replicon chromosome
Accession NZ_CP035952
Organism Pseudomonas sp. SNU WT1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag EXN22_RS08390 Protein ID WP_130263620.1
Coordinates 1813181..1814050 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EXN22_RS08385 Protein ID WP_130263619.1
Coordinates 1812357..1813184 (-) Length 276 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN22_RS08365 1807565..1809055 - 1491 WP_130263615.1 aldehyde dehydrogenase -
EXN22_RS08370 1809066..1809869 - 804 WP_130263616.1 aspartate dehydrogenase -
EXN22_RS08375 1809880..1811562 - 1683 WP_130263617.1 thiamine pyrophosphate-binding protein -
EXN22_RS08380 1811555..1812355 - 801 WP_130263618.1 SDR family oxidoreductase -
EXN22_RS08385 1812357..1813184 - 828 WP_130263619.1 IclR family transcriptional regulator Antitoxin
EXN22_RS08390 1813181..1814050 - 870 WP_130263620.1 alpha/beta hydrolase Toxin
EXN22_RS08395 1814055..1814594 - 540 WP_130263621.1 cupin domain-containing protein -
EXN22_RS08400 1814610..1815374 - 765 WP_130266779.1 SDR family oxidoreductase -
EXN22_RS08405 1815374..1816150 - 777 WP_130263622.1 ABC transporter permease -
EXN22_RS08410 1816180..1817178 - 999 WP_130263623.1 ABC transporter substrate-binding protein -
EXN22_RS08415 1817218..1818069 - 852 WP_130263624.1 ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(43-274)

Antitoxin

(134-256)


Sequences


Toxin        


Download         Length: 290 a.a.        Molecular weight: 30416.70 Da        Isoelectric Point: 7.0436

>T119118 WP_130263620.1 NZ_CP035952:c1814050-1813181 [Pseudomonas sp. SNU WT1]
MSHATDHSLASLKAQLQQRFTQRLVQLADGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSPHARVIAWDAPGYGDS
SPLATPAPQAPDYARRLLQLLDALNIDDCVLVGHSLGALSAAALACQHPQRLRRLVLISPARGYGDPARAEQAQQVRSQR
LHTLEQLGIAQMAQQRGAHMLSPAASAQALGWVQWNMARLQPRGYRQAVELLCGDDLLRYAASTVPCEVHCGAADSITPP
ADCQALAAALGAPFQLIAEAGHASPIEQPEAVASLLARAIEASLTGTAL

Download         Length: 870 bp

>T119118 NZ_CP035952:c1814050-1813181 [Pseudomonas sp. SNU WT1]
ATGTCGCACGCCACCGACCACTCGCTCGCAAGCCTCAAGGCCCAGTTGCAACAGCGCTTTACCCAGCGCCTGGTGCAACT
GGCCGACGGCGCCCAGGCGATCCGCGAAGCCGGGCACGGGCCTGCCATCGTGCTGCTGCACGGCATCGGCTCGGGCGCCG
CGTCCTGGCTGCAGGTGGCGTTGCAATTGAGCCCGCACGCCCGGGTGATCGCCTGGGATGCACCGGGCTATGGCGACTCA
AGCCCGCTGGCCACGCCTGCACCGCAAGCCCCTGACTATGCCCGGCGCCTGCTGCAATTGCTCGACGCGCTGAACATCGA
TGACTGCGTGCTGGTCGGCCATTCCCTCGGCGCCCTCAGCGCCGCGGCATTGGCCTGCCAGCATCCGCAACGGCTGCGCC
GCCTGGTGCTGATCAGCCCGGCCCGTGGTTATGGCGACCCAGCGCGCGCCGAGCAGGCACAACAGGTGCGCAGCCAACGC
CTGCACACCCTCGAACAACTGGGCATCGCCCAGATGGCCCAGCAGCGCGGCGCGCACATGCTCTCGCCTGCGGCCAGTGC
CCAGGCCCTGGGCTGGGTGCAATGGAACATGGCGCGCCTGCAGCCCCGGGGTTATCGCCAGGCCGTCGAGCTGCTGTGCG
GTGACGACCTGCTGCGCTACGCCGCAAGCACCGTGCCTTGCGAAGTCCATTGCGGTGCCGCCGACAGCATTACCCCGCCC
GCCGACTGCCAGGCCTTGGCGGCTGCGTTGGGTGCACCGTTCCAGCTGATTGCCGAGGCCGGCCACGCCAGCCCGATCGA
ACAACCCGAGGCCGTGGCAAGCCTGCTTGCCCGGGCCATCGAAGCCTCTCTGACAGGTACTGCGCTATGA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30452.85 Da        Isoelectric Point: 6.4973

>AT119118 WP_130263619.1 NZ_CP035952:c1813184-1812357 [Pseudomonas sp. SNU WT1]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPSVQVAHINF
DGLLGHVRGSADELSRLLNYTPHAGNGRVTALMRD

Download         Length: 828 bp

>AT119118 NZ_CP035952:c1813184-1812357 [Pseudomonas sp. SNU WT1]
ATGAATGATTCGGATCTGTTGAAAGACAACCAGGACAAGTACATCGTCCCCGGCCTTGAGCGCGGCCTGTTGCTGCTCTG
TGAATTCAGCCGGCAAAACCGCACCCTCACCGCGCCAGAACTGGCGCGGCGCCTGGAGCTGCCGCGCTCGACCATCTTCC
GCCTGCTGACCACCCTGGAAACCATGGGTTTCGTCACCCGCAGCGGCAATGAATACCGCCTGGGCATGTCGGTACTGCGC
CTGGGCTTCGAGTACCTGGCTTCGCTGGAGCTGACCGAACTGGGCCAGCCGCTGCTGGCGCGGCTGTGCGATCACCTGAA
CTACCCGAGCAACCTGGTGGTGCGCGACGGTCGCTCGATCGTTTATGTGGCCAAGGTGTCGCCGCCGTCGGTGTTCTCCA
GCGCGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTGGGGCGCATCCTGCTCGAAGACCTGAGCCTGGCC
GAGCTGCGCGAGCTGTACCCCGAGGAGCACCTGGAACAGCACTCGCCGTGCACGCCAAAAACCGTGCTGGAGCTGTTCGA
CCTGGTGCAGAGCGACCGTCAGCGTGGCTACGTCAGCGGCGAAGGCTTCTTCGAGTCGTCGATCTCGACCATCGCCGCCC
CGGTGCGCGATCACAGTGGTCGAGTGGTTGCCGCCATGGGCGTGACCATTCCCTCGGTGCAGGTTGCGCACATCAATTTC
GACGGTCTGCTCGGCCATGTCCGTGGCAGCGCCGACGAGCTGTCGCGCCTGCTCAACTACACCCCGCACGCTGGCAACGG
TCGCGTCACTGCGCTGATGAGGGATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References