Detailed information of TA system TA119115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3049318..3049877
• Replicon: chromosome
• Accession: NZ_CP035945
• Organism: Blautia producta strain PMF1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PMF13cell1_RS13455
• Protein ID: WP_130181033.1
• Coordinates: 3049593..3049877 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4P6LX53
• Locus tag: PMF13cell1_RS13450
• Protein ID: WP_029469812.1
• Coordinates: 3049318..3049596 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PMF13cell1_RS13425	3045398..3046048	+	651	WP_130181029.1	DUF3786 domain-containing protein	-
PMF13cell1_RS13430	3046162..3047178	+	1017	WP_130181030.1	nucleotidyltransferase domain-containing protein	-
PMF13cell1_RS13435	3047276..3047971	+	696	WP_130181031.1	HD domain-containing protein	-
PMF13cell1_RS13440	3047987..3048871	+	885	WP_130181032.1	radical SAM protein	-
PMF13cell1_RS13445	3049028..3049165	+	138	WP_029469813.1	helix-turn-helix domain-containing protein	-
PMF13cell1_RS13450	3049318..3049596	+	279	WP_029469812.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PMF13cell1_RS13455	3049593..3049877	+	285	WP_130181033.1	type II toxin-antitoxin system YafQ family toxin	Toxin
PMF13cell1_RS13460	3050257..3050853	+	597	WP_130183027.1	isoprenylcysteine carboxylmethyltransferase family protein	-
PMF13cell1_RS13465	3050904..3051839	+	936	WP_130181034.1	GNAT family N-acetyltransferase	-
PMF13cell1_RS13475	3051958..3052638	+	681	WP_018593541.1	TIGR00266 family protein	-
PMF13cell1_RS13480	3052717..3053739	+	1023	WP_130181035.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10694.49 Da
• Isoelectric Point: 9.5088

>T119115 WP_130181033.1 NZ_CP035945:3049593-3049877 [Blautia producta]
MTKYTVKPTTQFKKDYKLAIKRGLKIELLEEIIISLANGVPLPEKNKDHALGGNWNGHRECHILPDWLLVYRVENDVLVL
TLARAGTHSDLFGK

Nucleotide

• Length: 285 bp

>T119115 NZ_CP035945:3049593-3049877 [Blautia producta]
ATGACAAAATATACTGTTAAACCTACCACACAATTCAAGAAAGATTACAAGTTAGCAATCAAACGTGGATTGAAAATTGA
GCTATTAGAAGAAATCATCATCAGTCTTGCGAACGGTGTCCCGCTGCCGGAGAAAAACAAAGACCATGCTCTTGGTGGCA
ACTGGAACGGACATCGTGAGTGTCACATCTTACCTGATTGGTTACTTGTATATCGGGTGGAAAATGATGTTCTTGTCTTA
ACGTTGGCTCGCGCAGGCACACACAGCGACTTGTTTGGAAAATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10179.58 Da
• Isoelectric Point: 4.4367

>AT119115 WP_029469812.1 NZ_CP035945:3049318-3049596 [Blautia producta]
MTGNTTNISIRMDAELKSQADELFAELGMNISTAFNIFVRQALREGGIPFDVSLNKPNKETVTAMLEAERIAKDPAVKGY
TDLNQLFADLKE

Nucleotide

• Length: 279 bp

>AT119115 NZ_CP035945:3049318-3049596 [Blautia producta]
ATGACTGGCAATACAACCAACATCAGCATTCGCATGGATGCGGAACTAAAATCTCAAGCGGATGAGCTTTTTGCAGAGCT
CGGTATGAATATTTCCACGGCGTTTAATATTTTTGTTCGGCAAGCGCTTCGTGAGGGCGGTATTCCTTTTGATGTTTCGC
TGAATAAGCCAAATAAGGAGACCGTTACTGCAATGCTTGAAGCGGAAAGGATTGCGAAAGACCCTGCTGTTAAGGGCTAT
ACTGATCTCAATCAGCTTTTCGCAGATTTGAAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P6LX53