Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4698039..4698555 Replicon chromosome
Accession NZ_CP035929
Organism Klebsiella pneumoniae strain B31

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KpB31_RS23030 Protein ID WP_004178374.1
Coordinates 4698039..4698323 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KpB31_RS23035 Protein ID WP_002886901.1
Coordinates 4698313..4698555 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KpB31_RS23010 4693523..4693831 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
KpB31_RS26670 4693916..4694089 + 174 WP_032408826.1 hypothetical protein -
KpB31_RS23015 4694092..4694835 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KpB31_RS23020 4695192..4697330 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KpB31_RS23025 4697571..4698035 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KpB31_RS23030 4698039..4698323 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KpB31_RS23035 4698313..4698555 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KpB31_RS23040 4698633..4700543 - 1911 WP_004178373.1 BglG family transcription antiterminator -
KpB31_RS23045 4700566..4701720 - 1155 WP_004178372.1 lactonase family protein -
KpB31_RS23050 4701787..4702527 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T119089 WP_004178374.1 NZ_CP035929:c4698323-4698039 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T119089 NZ_CP035929:c4698323-4698039 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT119089 WP_002886901.1 NZ_CP035929:c4698555-4698313 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT119089 NZ_CP035929:c4698555-4698313 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References