Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 749381..750215 Replicon chromosome
Accession NZ_CP035929
Organism Klebsiella pneumoniae strain B31

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag KpB31_RS03700 Protein ID WP_000854808.1
Coordinates 749838..750215 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag KpB31_RS03695 Protein ID WP_001354276.1
Coordinates 749381..749749 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KpB31_RS03675 747042..747860 + 819 WP_001234702.1 DUF945 domain-containing protein -
KpB31_RS03680 747951..748436 + 486 WP_000214319.1 antirestriction protein -
KpB31_RS03685 748452..748928 + 477 WP_001354275.1 RadC family protein -
KpB31_RS03690 748997..749218 + 222 WP_000692345.1 DUF987 domain-containing protein -
KpB31_RS03695 749381..749749 + 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
KpB31_RS03700 749838..750215 + 378 WP_000854808.1 type IV toxin-antitoxin system toxin CbtA Toxin
KpB31_RS03705 750212..750700 + 489 WP_000761645.1 hypothetical protein -
KpB31_RS03710 750712..750909 + 198 WP_000839241.1 DUF957 domain-containing protein -
KpB31_RS03715 750994..751839 + 846 WP_001280440.1 DUF4942 domain-containing protein -
KpB31_RS03725 752138..752644 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
KpB31_RS03730 752744..754585 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T119075 WP_000854808.1 NZ_CP035929:749838-750215 [Klebsiella pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T119075 NZ_CP035929:749838-750215 [Klebsiella pneumoniae]
ATGAAAACATTACCTGTATTACCCGGTCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT119075 WP_001354276.1 NZ_CP035929:749381-749749 [Klebsiella pneumoniae]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT119075 NZ_CP035929:749381-749749 [Klebsiella pneumoniae]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References