Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 692619..693195 Replicon chromosome
Accession NZ_CP035928
Organism Malaciobacter pacificus strain LMG 26638

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag APAC_RS03485 Protein ID WP_130232796.1
Coordinates 692619..692918 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag APAC_RS03490 Protein ID WP_130232797.1
Coordinates 692911..693195 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APAC_RS03455 688178..689086 - 909 WP_130232790.1 chemotaxis protein CheW -
APAC_RS03460 689151..689801 - 651 WP_130232791.1 tRNA threonylcarbamoyladenosine dehydratase -
APAC_RS03465 689877..690362 + 486 WP_130232792.1 transcription elongation factor GreA -
APAC_RS03470 690362..691366 + 1005 WP_130232793.1 N-acetyl-gamma-glutamyl-phosphate reductase -
APAC_RS03475 691356..692057 + 702 WP_130232794.1 metallophosphoesterase -
APAC_RS03480 692054..692587 + 534 WP_130232795.1 hypothetical protein -
APAC_RS03485 692619..692918 + 300 WP_130232796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APAC_RS03490 692911..693195 + 285 WP_130232797.1 putative addiction module antidote protein Antitoxin
APAC_RS03495 693278..693508 + 231 WP_130232798.1 hypothetical protein -
APAC_RS03500 693694..695667 + 1974 WP_130232799.1 excinuclease ABC subunit UvrB -
APAC_RS03505 695701..695991 + 291 WP_130232800.1 nucleotidyltransferase family protein -
APAC_RS03510 695984..696424 + 441 WP_130232801.1 DUF86 domain-containing protein -
APAC_RS03515 696437..697093 + 657 WP_130232802.1 endonuclease III -
APAC_RS03520 697120..697350 + 231 WP_130232803.1 hypothetical protein -
APAC_RS03525 697354..697752 - 399 WP_130232804.1 hypothetical protein -
APAC_RS03530 697756..698001 - 246 WP_130232805.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11340.07 Da        Isoelectric Point: 9.6938

>T119072 WP_130232796.1 NZ_CP035928:692619-692918 [Malaciobacter pacificus]
MYLIKQTNIFSKWLSKLKDTQGKVAVLRRVERMKLGNFGDHKSVGNNINELRIPTGPGYRVYYTLKDDEIIVLLIGGDKS
SQSDDIKKANEILKELENE

Download         Length: 300 bp

>T119072 NZ_CP035928:692619-692918 [Malaciobacter pacificus]
ATGTATTTAATAAAACAAACAAATATCTTTTCAAAATGGCTATCAAAACTCAAAGATACTCAAGGTAAAGTTGCTGTATT
AAGAAGAGTTGAGAGAATGAAATTAGGAAACTTTGGAGATCATAAATCAGTTGGTAATAATATAAATGAACTTAGAATTC
CAACAGGTCCAGGATATAGAGTTTACTATACTTTAAAAGATGATGAAATTATTGTTTTATTAATTGGTGGAGATAAATCA
TCACAAAGTGATGATATTAAAAAAGCAAATGAGATTTTAAAGGAGCTTGAAAATGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10283.81 Da        Isoelectric Point: 4.7672

>AT119072 WP_130232797.1 NZ_CP035928:692911-693195 [Malaciobacter pacificus]
MSNVELTNFDIAQYLDNKEVIAEYLSQILADGDMDELLEALGNIAKAKGMSQIASETGLGRESLYKTFHKGTKPKFDTIM
KVISSLGVKVQVTA

Download         Length: 285 bp

>AT119072 NZ_CP035928:692911-693195 [Malaciobacter pacificus]
ATGAGTAATGTAGAACTTACAAACTTTGATATAGCACAATATCTTGATAATAAAGAAGTAATAGCTGAATATCTATCTCA
AATTTTAGCTGATGGTGATATGGATGAATTACTTGAAGCTCTAGGAAATATTGCAAAAGCAAAAGGTATGAGCCAAATTG
CAAGTGAAACTGGATTAGGTAGAGAAAGTTTATATAAAACTTTTCATAAAGGTACAAAACCTAAATTTGATACAATTATG
AAAGTAATTAGTTCACTTGGAGTTAAAGTCCAAGTAACAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References