Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3838705..3839279 Replicon chromosome
Accession NZ_CP035925
Organism Lentibacillus sp. CBA3610

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Len3610_RS19220 Protein ID WP_176449752.1
Coordinates 3838705..3839040 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Len3610_RS19225 Protein ID WP_176449336.1
Coordinates 3839040..3839279 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Len3610_RS19200 3834584..3835717 + 1134 WP_176449332.1 N-acetyldiaminopimelate deacetylase -
Len3610_RS19205 3836059..3836967 - 909 WP_176449333.1 diaminopimelate epimerase -
Len3610_RS19210 3837337..3837438 + 102 WP_176449334.1 CGNR zinc finger domain-containing protein -
Len3610_RS19215 3837939..3838316 - 378 WP_176449335.1 hypothetical protein -
Len3610_RS19220 3838705..3839040 - 336 WP_176449752.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Len3610_RS19225 3839040..3839279 - 240 WP_176449336.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Len3610_RS19230 3839919..3840179 - 261 WP_176449337.1 hypothetical protein -
Len3610_RS19235 3840723..3841421 + 699 WP_176449338.1 hypothetical protein -
Len3610_RS19240 3841767..3842417 + 651 WP_176449339.1 hypothetical protein -
Len3610_RS19245 3842497..3843003 - 507 WP_176449340.1 hypothetical protein -
Len3610_RS19250 3844068..3844259 + 192 WP_176449341.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12638.58 Da        Isoelectric Point: 6.4571

>T119069 WP_176449752.1 NZ_CP035925:c3839040-3838705 [Lentibacillus sp. CBA3610]
MVLEQGDLIYINFSPQSGHEQRGMRPAIVLSPSLFNQGAFIAVCPITKEKKGYPFEIELPDDLPVYGVILTDQIRTLDWR
SRSAGLKGKAPQEIVEKCFNRIHTYLTMDER

Download         Length: 336 bp

>T119069 NZ_CP035925:c3839040-3838705 [Lentibacillus sp. CBA3610]
ATGGTATTGGAACAAGGAGATTTAATTTATATTAACTTCAGCCCGCAGTCCGGGCATGAGCAAAGAGGTATGCGTCCGGC
CATCGTACTGTCACCCAGCTTATTCAATCAAGGGGCATTCATCGCAGTCTGCCCCATCACGAAAGAGAAAAAAGGCTATC
CATTTGAGATTGAACTACCAGACGACCTCCCGGTGTATGGTGTCATTCTCACGGATCAAATAAGAACGTTGGACTGGCGT
TCCAGGTCAGCAGGCCTCAAAGGAAAAGCACCGCAAGAGATAGTTGAAAAATGCTTCAATCGAATTCATACTTATTTAAC
GATGGATGAGCGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8862.00 Da        Isoelectric Point: 4.7947

>AT119069 WP_176449336.1 NZ_CP035925:c3839279-3839040 [Lentibacillus sp. CBA3610]
MSTTAQKWGNSIGVRIPQKIAKKYNIVNGSELEISEDNQGIILKPVSKEPSLEELMAGITKENQHEEINWGKPEGNEVW

Download         Length: 240 bp

>AT119069 NZ_CP035925:c3839279-3839040 [Lentibacillus sp. CBA3610]
ATGTCAACAACTGCTCAAAAGTGGGGAAACAGCATCGGTGTTCGTATTCCCCAAAAGATAGCAAAAAAGTATAACATCGT
AAATGGTTCCGAGCTGGAAATCAGTGAAGACAATCAAGGTATTATATTAAAACCAGTTTCTAAAGAACCTTCCTTGGAGG
AATTAATGGCCGGGATCACAAAGGAAAACCAGCACGAAGAGATTAACTGGGGTAAGCCGGAAGGGAACGAAGTTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References