Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3583937..3584496 Replicon chromosome
Accession NZ_CP035925
Organism Lentibacillus sp. CBA3610

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Len3610_RS17855 Protein ID WP_176449134.1
Coordinates 3583937..3584263 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Len3610_RS17860 Protein ID WP_176449135.1
Coordinates 3584263..3584496 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Len3610_RS17830 3579035..3579520 + 486 WP_176449129.1 DUF456 family protein -
Len3610_RS17835 3579542..3580372 + 831 WP_176449130.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
Len3610_RS17840 3580554..3581105 + 552 WP_176449131.1 cysteine hydrolase -
Len3610_RS17845 3581203..3581736 + 534 WP_176449132.1 GNAT family N-acetyltransferase -
Len3610_RS17850 3582054..3583490 + 1437 WP_176449133.1 proline--tRNA ligase -
Len3610_RS17855 3583937..3584263 - 327 WP_176449134.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Len3610_RS17860 3584263..3584496 - 234 WP_176449135.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Len3610_RS17865 3584931..3585410 - 480 WP_176449740.1 glutathione peroxidase -
Len3610_RS17870 3585770..3586045 - 276 WP_176449136.1 type II toxin-antitoxin system RelE/ParE family toxin -
Len3610_RS17875 3586046..3586267 - 222 WP_176449137.1 hypothetical protein -
Len3610_RS17880 3586508..3587494 - 987 WP_176449138.1 rhodanese-related sulfurtransferase -
Len3610_RS17885 3587777..3587977 + 201 WP_176449139.1 cold shock domain-containing protein -
Len3610_RS17890 3588072..3588761 + 690 WP_176449140.1 class I SAM-dependent methyltransferase -
Len3610_RS17895 3588763..3589071 + 309 WP_176449141.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-106)

Antitoxin

SpoVT-AbrB domain

(5-48)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12118.86 Da        Isoelectric Point: 8.5326

>T119068 WP_176449134.1 NZ_CP035925:c3584263-3583937 [Lentibacillus sp. CBA3610]
MQCPDRGDFIFLDFDPQAGTEQAGHRLAIVLSPKRFNEVTGYATVCPVSRTDRKWGFHIQIPDDAVVGGVVIADQMKNLD
WRTRNARIAGQAPNNLVNRVVKVIHTYI

Download         Length: 327 bp

>T119068 NZ_CP035925:c3584263-3583937 [Lentibacillus sp. CBA3610]
ATGCAATGTCCAGACCGAGGGGATTTCATCTTTTTAGATTTTGACCCCCAAGCAGGAACAGAGCAAGCAGGACACAGACT
CGCAATTGTGCTTTCACCAAAGCGTTTTAATGAGGTCACAGGCTACGCAACGGTTTGTCCGGTCAGCCGAACAGATAGAA
AATGGGGTTTCCATATCCAGATTCCAGATGATGCGGTAGTCGGGGGAGTAGTCATTGCCGATCAAATGAAAAACTTGGAT
TGGAGAACGAGGAATGCACGAATCGCAGGACAAGCACCTAACAACCTTGTCAATAGAGTTGTTAAGGTGATACATACTTA
TATATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8475.48 Da        Isoelectric Point: 4.3440

>AT119068 WP_176449135.1 NZ_CP035925:c3584496-3584263 [Lentibacillus sp. CBA3610]
MTTVQKWGGSLGVRIPKSIADRFGVQDGSKVNVKADEKGIFIEPADDEPTLEDLLAQCEGGNPHEEFFSRPMGREEI

Download         Length: 234 bp

>AT119068 NZ_CP035925:c3584496-3584263 [Lentibacillus sp. CBA3610]
ATGACGACTGTTCAAAAATGGGGCGGCAGTCTTGGGGTACGCATTCCTAAGTCAATAGCAGATCGTTTCGGTGTGCAGGA
CGGCTCCAAAGTGAATGTAAAAGCTGACGAAAAAGGGATCTTTATTGAGCCAGCCGATGATGAGCCAACGCTTGAAGATC
TTTTGGCGCAATGTGAAGGGGGTAATCCCCACGAAGAATTTTTCAGCAGACCAATGGGGAGGGAAGAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References