Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1204003..1204613 Replicon chromosome
Accession NZ_CP035914
Organism Synechococcus sp. WH 8101

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag SynWH8101_RS06285 Protein ID WP_130129025.1
Coordinates 1204003..1204305 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag SynWH8101_RS06290 Protein ID WP_130129026.1
Coordinates 1204305..1204613 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynWH8101_RS06265 1199478..1201109 - 1632 WP_130129021.1 hypothetical protein -
SynWH8101_RS06270 1201109..1202155 - 1047 WP_130129022.1 hypothetical protein -
SynWH8101_RS06275 1202391..1203131 + 741 WP_130129023.1 hypothetical protein -
SynWH8101_RS14090 1203167..1203337 - 171 WP_165380942.1 hypothetical protein -
SynWH8101_RS06285 1204003..1204305 + 303 WP_130129025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SynWH8101_RS06290 1204305..1204613 + 309 WP_130129026.1 putative addiction module antidote protein Antitoxin
SynWH8101_RS06295 1204709..1205458 + 750 WP_130129027.1 GNAT family N-acetyltransferase -
SynWH8101_RS06300 1205929..1206111 - 183 WP_130129028.1 hypothetical protein -
SynWH8101_RS06305 1206111..1206395 - 285 WP_130129029.1 hypothetical protein -
SynWH8101_RS06310 1206987..1207199 + 213 WP_130129030.1 hypothetical protein -
SynWH8101_RS06315 1207215..1207535 - 321 WP_130129031.1 hypothetical protein -
SynWH8101_RS06320 1207569..1208312 - 744 WP_130129032.1 fatty acid desaturase -
SynWH8101_RS06325 1208302..1209273 - 972 WP_130129033.1 orange carotenoid-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1191158..1220972 29814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11207.76 Da        Isoelectric Point: 10.4145

>T119065 WP_130129025.1 NZ_CP035914:1204003-1204305 [Synechococcus sp. WH 8101]
VVEVRQTERFAQWLGDLRDLRARARVQARIERLIGGNPGDVKPIGSGVSELRINYGPGYRVYFQQKGSTLIILLAGGDKS
SQSRDIEEALLLARQITENR

Download         Length: 303 bp

>T119065 NZ_CP035914:1204003-1204305 [Synechococcus sp. WH 8101]
GTGGTTGAAGTTCGGCAAACAGAGCGCTTTGCGCAATGGCTGGGGGATCTACGTGATCTCAGGGCCCGAGCGCGCGTTCA
GGCCAGGATTGAGCGTCTTATTGGCGGCAATCCGGGTGACGTCAAACCCATTGGTTCTGGTGTCTCAGAGTTGAGAATCA
ACTACGGCCCTGGTTACAGGGTCTACTTCCAGCAAAAAGGCTCCACGTTGATCATCCTCTTGGCTGGTGGCGATAAGTCA
TCACAATCAAGAGACATCGAGGAAGCTCTCTTGCTGGCTCGTCAGATCACGGAGAACCGTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10876.47 Da        Isoelectric Point: 4.6181

>AT119065 WP_130129026.1 NZ_CP035914:1204305-1204613 [Synechococcus sp. WH 8101]
MKIKTLPYDVAETLRTPDEMAAYLEACIEDADGDAAFIAKALGDIARAQGMTQIARQTGLSRESLYKALSGDRSPSFDTV
LKVISALGLKLSAGVQEKAEVV

Download         Length: 309 bp

>AT119065 NZ_CP035914:1204305-1204613 [Synechococcus sp. WH 8101]
ATGAAGATCAAGACTCTGCCCTACGACGTCGCTGAGACACTTAGAACACCTGACGAAATGGCGGCCTATCTCGAGGCATG
CATCGAGGATGCCGATGGCGATGCTGCCTTCATTGCCAAGGCTCTTGGCGATATCGCTCGTGCTCAGGGGATGACGCAGA
TCGCTCGCCAGACAGGACTCTCTCGCGAAAGCCTGTACAAAGCGCTGTCTGGTGATCGCAGCCCTAGTTTTGACACTGTT
CTCAAAGTGATCTCCGCGCTCGGATTAAAACTGAGTGCCGGAGTTCAGGAGAAGGCTGAGGTCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References