Detailed information of TA system TA119064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1160422..1160929
• Replicon: chromosome
• Accession: NZ_CP035914
• Organism: Synechococcus sp. WH 8101

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SynWH8101_RS05970
• Protein ID: WP_130128976.1
• Coordinates: 1160422..1160685 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SynWH8101_RS05975
• Protein ID: WP_130128977.1
• Coordinates: 1160672..1160929 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynWH8101_RS05935	1155807..1156004	-	198	WP_130128971.1	hypothetical protein	-
SynWH8101_RS05940	1156166..1156906	-	741	WP_130130380.1	type 1 glutamine amidotransferase	-
SynWH8101_RS05945	1157147..1157557	-	411	WP_130128972.1	hypothetical protein	-
SynWH8101_RS05950	1158108..1158593	+	486	WP_165380936.1	hypothetical protein	-
SynWH8101_RS05955	1158689..1159342	+	654	WP_130128973.1	siphovirus Gp157 family protein	-
SynWH8101_RS05960	1159335..1159532	-	198	WP_130128974.1	hypothetical protein	-
SynWH8101_RS05965	1159531..1160367	+	837	WP_130128975.1	RAD52 family DNA repair protein	-
SynWH8101_RS05970	1160422..1160685	+	264	WP_130128976.1	BrnT family toxin	Toxin
SynWH8101_RS05975	1160672..1160929	+	258	WP_130128977.1	CopG family transcriptional regulator	Antitoxin
SynWH8101_RS05980	1161026..1161265	+	240	WP_130128978.1	DUF433 domain-containing protein	-
SynWH8101_RS05985	1161265..1161585	+	321	WP_130128979.1	hypothetical protein	-
SynWH8101_RS05990	1161684..1161974	-	291	WP_130130382.1	hypothetical protein	-
SynWH8101_RS05995	1162638..1163828	+	1191	WP_130128980.1	agmatinase	-
SynWH8101_RS06000	1163832..1164212	+	381	WP_130128981.1	hydrogenase maturation nickel metallochaperone HypA	-
SynWH8101_RS06005	1164215..1164919	+	705	WP_130128982.1	hydrogenase nickel incorporation protein HypB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1143702..1169366	25664

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10125.56 Da
• Isoelectric Point: 8.7288

>T119064 WP_130128976.1 NZ_CP035914:1160422-1160685 [Synechococcus sp. WH 8101]
MDFEFDPRKSQANLEKHGIDFIAAQALWGDPALLEIPARPADEPRWLVIGRIQSKHWSAVITRRGQATRLISVRRSRPEE
IQLYEQF

Nucleotide

• Length: 264 bp

>T119064 NZ_CP035914:1160422-1160685 [Synechococcus sp. WH 8101]
ATGGACTTTGAATTCGATCCACGTAAAAGCCAGGCCAATCTGGAAAAGCACGGCATCGATTTCATTGCTGCGCAGGCGTT
ATGGGGAGATCCTGCTCTGTTGGAGATCCCCGCCCGCCCGGCCGATGAACCACGTTGGCTTGTGATTGGTCGAATCCAGA
GCAAACACTGGTCAGCCGTGATCACAAGGCGCGGTCAGGCCACTCGATTGATTTCTGTTCGCCGTTCACGCCCTGAGGAG
ATTCAGCTCTATGAACAGTTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9926.10 Da
• Isoelectric Point: 5.8703

>AT119064 WP_130128977.1 NZ_CP035914:1160672-1160929 [Synechococcus sp. WH 8101]
MNSSEFDRRFDSGESVLEGLDLESARRPRLEQKRVNVDFPLWMVDQLDREASRLGVTRQSIIKVWLSERLEHQRGVDPTQ
VSGNR

Nucleotide

• Length: 258 bp

>AT119064 NZ_CP035914:1160672-1160929 [Synechococcus sp. WH 8101]
ATGAACAGTTCTGAATTTGATCGACGCTTTGACAGCGGTGAGTCCGTTCTGGAGGGCTTGGATCTGGAGTCCGCCCGGCG
ACCTCGCTTGGAGCAGAAACGCGTCAATGTCGATTTTCCGCTCTGGATGGTGGATCAATTGGATCGAGAAGCGTCGCGTC
TCGGTGTAACGCGCCAATCGATCATCAAGGTATGGCTCTCAGAGCGGCTCGAGCATCAACGCGGTGTCGACCCCACCCAG
GTTTCAGGCAACCGTTGA