Detailed information of TA system TA119063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1016251..1016948
• Replicon: chromosome
• Accession: NZ_CP035914
• Organism: Synechococcus sp. WH 8101

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SynWH8101_RS05105
• Protein ID: WP_130130358.1
• Coordinates: 1016251..1016673 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SynWH8101_RS05110
• Protein ID: WP_130128843.1
• Coordinates: 1016691..1016948 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SynWH8101_RS05100	1013342..1016254	-	2913	WP_130128842.1	DUF1156 domain-containing protein	-
SynWH8101_RS05105	1016251..1016673	-	423	WP_130130358.1	type II toxin-antitoxin system VapC family toxin	Toxin
SynWH8101_RS05110	1016691..1016948	-	258	WP_130128843.1	plasmid stabilization protein	Antitoxin
SynWH8101_RS05115	1017055..1017288	+	234	WP_130128844.1	addiction module protein	-
SynWH8101_RS05120	1017269..1017571	+	303	WP_130128845.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SynWH8101_RS05125	1017583..1021110	-	3528	WP_130128846.1	DUF3883 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15211.32 Da
• Isoelectric Point: 5.5743

>T119063 WP_130130358.1 NZ_CP035914:c1016673-1016251 [Synechococcus sp. WH 8101]
VIVLDTNVISELMRPQPDQRVLAWANSLDPESAAITAMNEAEILHGLARLPGGRRKQALRESWDALAADLFAGRVWAFTS
EAAHWYGELVSHRERLARPIATADAVIAAIGLAHGAPLATRNTSDFADLGLQLINPWTIP

Nucleotide

• Length: 423 bp

>T119063 NZ_CP035914:c1016673-1016251 [Synechococcus sp. WH 8101]
GTGATCGTTCTCGACACCAACGTGATCTCCGAGCTGATGCGTCCGCAGCCGGATCAACGGGTTCTGGCCTGGGCCAACAG
CCTCGATCCAGAGAGCGCAGCGATCACCGCCATGAACGAAGCGGAGATCCTGCACGGCCTGGCGCGCCTGCCGGGTGGAC
GCCGCAAGCAGGCACTGCGCGAGAGCTGGGATGCACTGGCAGCCGACCTGTTTGCAGGTCGGGTGTGGGCCTTCACCAGC
GAGGCCGCTCATTGGTATGGCGAGCTGGTGAGCCACCGCGAACGCCTGGCTCGGCCGATCGCCACCGCCGATGCCGTGAT
CGCAGCCATCGGCCTGGCCCACGGCGCTCCGCTGGCCACCCGTAACACCTCTGATTTCGCCGATCTCGGCCTGCAGCTGA
TCAATCCCTGGACCATCCCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9480.67 Da
• Isoelectric Point: 6.2304

>AT119063 WP_130128843.1 NZ_CP035914:c1016948-1016691 [Synechococcus sp. WH 8101]
MATLTIRNLDERTKAQLRVQAARHGRSMEEEARTILRTAIESSQAEVQVERLGSRIHAHFAELGGVELDLLERSSAPAAA
EFEPR

Nucleotide

• Length: 258 bp

>AT119063 NZ_CP035914:c1016948-1016691 [Synechococcus sp. WH 8101]
ATGGCCACCCTCACCATCCGTAATCTCGACGAGCGCACCAAGGCTCAGCTGCGCGTGCAGGCCGCCCGCCATGGCCGATC
CATGGAGGAAGAAGCGCGCACGATCCTGCGAACAGCGATCGAATCCAGCCAGGCTGAGGTGCAGGTGGAGCGCCTGGGCA
GCCGCATCCATGCCCATTTCGCTGAGCTGGGCGGTGTGGAGCTCGATCTGCTGGAGCGCAGCTCAGCCCCTGCAGCCGCT
GAGTTCGAGCCACGCTGA