Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2307931..2308706 Replicon chromosome
Accession NZ_CP035901
Organism Burkholderia glumae strain 257sh-1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag EXE55_RS25700 Protein ID WP_017423245.1
Coordinates 2308209..2308706 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag EXE55_RS25695 Protein ID WP_161521884.1
Coordinates 2307931..2308212 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXE55_RS29555 2307238..2307675 + 438 WP_169511094.1 SMI1/KNR4 family protein -
EXE55_RS25695 2307931..2308212 + 282 WP_161521884.1 DUF1778 domain-containing protein Antitoxin
EXE55_RS25700 2308209..2308706 + 498 WP_017423245.1 GNAT family N-acetyltransferase Toxin
EXE55_RS25705 2308787..2309269 + 483 WP_161521885.1 ProQ activator of osmoprotectant transporter prop -
EXE55_RS25710 2309626..2310561 + 936 Protein_1940 RHS domain-containing protein -
EXE55_RS25715 2310578..2310862 + 285 WP_153478924.1 hypothetical protein -
EXE55_RS25720 2310985..2311530 + 546 Protein_1942 IS3 family transposase -
EXE55_RS25725 2311783..2313132 - 1350 WP_161521886.1 allantoin permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2295566..2319205 23639
- flank IS/Tn - - 2311012..2311554 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17606.19 Da        Isoelectric Point: 9.6894

>T119059 WP_017423245.1 NZ_CP035901:2308209-2308706 [Burkholderia glumae]
MTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRSLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T119059 NZ_CP035901:2308209-2308706 [Burkholderia glumae]
ATGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCGGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCAGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10226.50 Da        Isoelectric Point: 5.0477

>AT119059 WP_161521884.1 NZ_CP035901:2307931-2308212 [Burkholderia glumae]
MASTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT119059 NZ_CP035901:2307931-2308212 [Burkholderia glumae]
ATGGCCTCGACCACCCCGCGCGACACCCTGAACTTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTCCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGCCTGGACGAGCCGGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCTTGGGACCCCGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References