Detailed information of TA system TA119056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 999947..1000445
• Replicon: chromosome
• Accession: NZ_CP035897
• Organism: Streptococcus pneumoniae strain EF3030

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EF3030_RS05335
• Protein ID: WP_001812387.1
• Coordinates: 1000191..1000445 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EF3030_RS05330
• Protein ID: WP_000208080.1
• Coordinates: 999947..1000189 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EF3030_RS05310	995769..996944	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
EF3030_RS05315	996999..997703	+	705	WP_000722076.1	response regulator transcription factor	-
EF3030_RS05320	997696..999045	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EF3030_RS05325	999047..999856	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EF3030_RS05330	999947..1000189	+	243	WP_000208080.1	hypothetical protein	Antitoxin
EF3030_RS05335	1000191..1000445	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EF3030_RS05340	1000492..1001144	+	653	Protein_996	potassium channel family protein	-
EF3030_RS05345	1001404..1002390	-	987	WP_000204727.1	L-lactate dehydrogenase	-
EF3030_RS05350	1002584..1005052	+	2469	WP_001152992.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T119056 WP_001812387.1 NZ_CP035897:1000191-1000445 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T119056 NZ_CP035897:1000191-1000445 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT119056 WP_000208080.1 NZ_CP035897:999947-1000189 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT119056 NZ_CP035897:999947-1000189 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7