Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4423139..4423974 Replicon chromosome
Accession NZ_CP035884
Organism Escherichia coli strain LSN03-016011/A

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EW995_RS21085 Protein ID WP_001391462.1
Coordinates 4423597..4423974 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EW995_RS21080 Protein ID WP_024169392.1
Coordinates 4423139..4423507 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW995_RS21045 (4419098) 4419098..4419580 + 483 WP_024169391.1 hypothetical protein -
EW995_RS21050 (4419682) 4419682..4419918 + 237 WP_032245254.1 DUF905 family protein -
EW995_RS21055 (4420018) 4420018..4420836 + 819 WP_001234729.1 DUF932 domain-containing protein -
EW995_RS21060 (4421178) 4421178..4421651 + 474 WP_001391480.1 antirestriction protein -
EW995_RS21065 (4421667) 4421667..4422143 + 477 WP_001391468.1 RadC family protein -
EW995_RS21070 (4422206) 4422206..4422427 + 222 WP_000692291.1 DUF987 domain-containing protein -
EW995_RS21075 (4422446) 4422446..4423089 + 644 Protein_4111 antitoxin of toxin-antitoxin stability system -
EW995_RS21080 (4423139) 4423139..4423507 + 369 WP_024169392.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW995_RS21085 (4423597) 4423597..4423974 + 378 WP_001391462.1 TA system toxin CbtA family protein Toxin
EW995_RS21090 (4423971) 4423971..4424459 + 489 WP_001391459.1 DUF5983 family protein -
EW995_RS21095 (4424476) 4424476..4424673 + 198 WP_001391464.1 DUF957 domain-containing protein -
EW995_RS21100 (4424758) 4424758..4425600 + 843 WP_001340503.1 DUF4942 domain-containing protein -
EW995_RS21110 (4426072) 4426072..4427010 + 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
EW995_RS21115 (4427065) 4427065..4427802 + 738 WP_000283664.1 zinc-binding phosphatase -
EW995_RS21120 (4427826) 4427826..4428380 + 555 WP_001001902.1 molecular chaperone YcdY -
EW995_RS21125 (4428482) 4428482..4428973 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 4405839..4435737 29898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14133.09 Da        Isoelectric Point: 7.8045

>T119043 WP_001391462.1 NZ_CP035884:4423597-4423974 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T119043 NZ_CP035884:4423597-4423974 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCTGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGTCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13672.45 Da        Isoelectric Point: 6.7389

>AT119043 WP_024169392.1 NZ_CP035884:4423139-4423507 [Escherichia coli]
VSDKLHETTHPDDNNNRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCAADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT119043 NZ_CP035884:4423139-4423507 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAACGCATCCCGATGACAATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGCAGCCGATACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References