Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 56048..56574 | Replicon | chromosome |
| Accession | NZ_CP035884 | ||
| Organism | Escherichia coli strain LSN03-016011/A | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EW995_RS00360 | Protein ID | WP_000323025.1 |
| Coordinates | 56048..56335 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EW995_RS00365 | Protein ID | WP_000534858.1 |
| Coordinates | 56335..56574 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EW995_RS00310 (51073) | 51073..51288 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| EW995_RS00315 (51507) | 51507..51677 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| EW995_RS00320 (52041) | 52041..52256 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EW995_RS00325 (52557) | 52557..52769 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EW995_RS00330 (52824) | 52824..52913 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| EW995_RS00335 (53191) | 53191..53943 | - | 753 | WP_001047135.1 | antitermination protein | - |
| EW995_RS00340 (53957) | 53957..55006 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| EW995_RS00345 (55008) | 55008..55286 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| EW995_RS00350 (55353) | 55353..55604 | - | 252 | WP_000980994.1 | protein Rem | - |
| EW995_RS00355 (55821) | 55821..55976 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EW995_RS00360 (56048) | 56048..56335 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EW995_RS00365 (56335) | 56335..56574 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EW995_RS00370 (56599) | 56599..56904 | + | 306 | WP_001326990.1 | protein YdfV | - |
| EW995_RS00375 (57107) | 57107..57439 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| EW995_RS25120 (57876) | 57876..58025 | - | 150 | WP_011443592.1 | protein YdfW | - |
| EW995_RS00380 (58146) | 58146..59168 | - | 1023 | Protein_76 | ISNCY family transposase | - |
| EW995_RS00385 (59958) | 59958..60245 | - | 288 | Protein_77 | hypothetical protein | - |
| EW995_RS00390 (60723) | 60723..61212 | - | 490 | Protein_78 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 18040..72519 | 54479 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T119019 WP_000323025.1 NZ_CP035884:c56335-56048 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T119019 NZ_CP035884:c56335-56048 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT119019 WP_000534858.1 NZ_CP035884:c56574-56335 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT119019 NZ_CP035884:c56574-56335 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|