Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3710594..3711428 Replicon chromosome
Accession NZ_CP035882
Organism Escherichia coli strain WS0115A

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EW996_RS18085 Protein ID WP_074503007.1
Coordinates 3711051..3711428 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EW996_RS18080 Protein ID WP_024183700.1
Coordinates 3710594..3710962 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW996_RS18045 (3706319) 3706319..3707203 + 885 WP_053291272.1 50S ribosome-binding GTPase -
EW996_RS18050 (3707322) 3707322..3707999 + 678 WP_074504021.1 hypothetical protein -
EW996_RS18055 (3708005) 3708005..3708238 + 234 WP_001278281.1 DUF905 family protein -
EW996_RS18060 (3708337) 3708337..3709155 + 819 WP_074503010.1 DUF932 domain-containing protein -
EW996_RS18065 (3709247) 3709247..3709732 + 486 WP_000206660.1 antirestriction protein -
EW996_RS18070 (3709748) 3709748..3710224 + 477 WP_074503008.1 RadC family protein -
EW996_RS18075 (3710293) 3710293..3710514 + 222 WP_000692295.1 DUF987 domain-containing protein -
EW996_RS18080 (3710594) 3710594..3710962 + 369 WP_024183700.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW996_RS18085 (3711051) 3711051..3711428 + 378 WP_074503007.1 TA system toxin CbtA family protein Toxin
EW996_RS18090 (3711425) 3711425..3711913 + 489 WP_074503005.1 DUF5983 family protein -
EW996_RS18095 (3711925) 3711925..3712121 + 197 Protein_3554 hypothetical protein -
EW996_RS18100 (3712206) 3712206..3713079 + 874 Protein_3555 DUF4942 domain-containing protein -
EW996_RS18105 (3713151) 3713151..3713414 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
EW996_RS18110 (3713411) 3713411..3713737 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
EW996_RS18115 (3714620) 3714620..3716158 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14349.38 Da        Isoelectric Point: 9.2442

>T119007 WP_074503007.1 NZ_CP035882:3711051-3711428 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T119007 NZ_CP035882:3711051-3711428 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13617.41 Da        Isoelectric Point: 7.7474

>AT119007 WP_024183700.1 NZ_CP035882:3710594-3710962 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT119007 NZ_CP035882:3710594-3710962 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAATTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References