Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2875279..2875897 Replicon chromosome
Accession NZ_CP035882
Organism Escherichia coli strain WS0115A

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EW996_RS13945 Protein ID WP_001291435.1
Coordinates 2875679..2875897 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag EW996_RS13940 Protein ID WP_074502734.1
Coordinates 2875279..2875653 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW996_RS13930 (2870368) 2870368..2871561 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EW996_RS13935 (2871584) 2871584..2874733 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
EW996_RS13940 (2875279) 2875279..2875653 + 375 WP_074502734.1 Hha toxicity modulator TomB Antitoxin
EW996_RS13945 (2875679) 2875679..2875897 + 219 WP_001291435.1 HHA domain-containing protein Toxin
EW996_RS13950 (2876069) 2876069..2876620 + 552 WP_000102564.1 maltose O-acetyltransferase -
EW996_RS13955 (2876736) 2876736..2877206 + 471 WP_000136192.1 YlaC family protein -
EW996_RS13960 (2877370) 2877370..2878920 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EW996_RS13965 (2878962) 2878962..2879315 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EW996_RS13975 (2879694) 2879694..2880005 + 312 WP_000409911.1 MGMT family protein -
EW996_RS13980 (2880036) 2880036..2880608 - 573 WP_074502732.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119003 WP_001291435.1 NZ_CP035882:2875679-2875897 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T119003 NZ_CP035882:2875679-2875897 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14543.32 Da        Isoelectric Point: 4.5917

>AT119003 WP_074502734.1 NZ_CP035882:2875279-2875653 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRNSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT119003 NZ_CP035882:2875279-2875653 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAACTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTCTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References