Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1662000..1662526 | Replicon | chromosome |
| Accession | NZ_CP035882 | ||
| Organism | Escherichia coli strain WS0115A | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EW996_RS07975 | Protein ID | WP_000323025.1 |
| Coordinates | 1662239..1662526 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EW996_RS07970 | Protein ID | WP_000534858.1 |
| Coordinates | 1662000..1662239 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EW996_RS07945 (1657362) | 1657362..1657851 | + | 490 | Protein_1553 | class I SAM-dependent methyltransferase | - |
| EW996_RS07950 (1658329) | 1658329..1658750 | + | 422 | Protein_1554 | hypothetical protein | - |
| EW996_RS07955 (1659406) | 1659406..1660428 | + | 1023 | Protein_1555 | ISNCY family transposase | - |
| EW996_RS24510 (1660549) | 1660549..1660698 | + | 150 | WP_011443592.1 | protein YdfW | - |
| EW996_RS07960 (1661135) | 1661135..1661467 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| EW996_RS07965 (1661670) | 1661670..1661975 | - | 306 | WP_001326990.1 | protein YdfV | - |
| EW996_RS07970 (1662000) | 1662000..1662239 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EW996_RS07975 (1662239) | 1662239..1662526 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EW996_RS07980 (1662598) | 1662598..1662753 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EW996_RS07985 (1662970) | 1662970..1663221 | + | 252 | WP_000980994.1 | protein Rem | - |
| EW996_RS07990 (1663288) | 1663288..1663566 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| EW996_RS07995 (1663568) | 1663568..1664617 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| EW996_RS08000 (1664631) | 1664631..1665383 | + | 753 | WP_001047135.1 | antitermination protein | - |
| EW996_RS08005 (1665661) | 1665661..1665750 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| EW996_RS08010 (1665805) | 1665805..1666017 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EW996_RS08015 (1666318) | 1666318..1666533 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EW996_RS08020 (1666897) | 1666897..1667067 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| EW996_RS08025 (1667287) | 1667287..1667502 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1642139..1708899 | 66760 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T118999 WP_000323025.1 NZ_CP035882:1662239-1662526 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T118999 NZ_CP035882:1662239-1662526 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT118999 WP_000534858.1 NZ_CP035882:1662000-1662239 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT118999 NZ_CP035882:1662000-1662239 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|