Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1784760..1785378 Replicon chromosome
Accession NZ_CP035879
Organism Escherichia coli strain DS26-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EW997_RS09180 Protein ID WP_001291435.1
Coordinates 1785160..1785378 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EW997_RS09175 Protein ID WP_000344800.1
Coordinates 1784760..1785134 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW997_RS09165 (1779849) 1779849..1781042 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EW997_RS09170 (1781065) 1781065..1784214 + 3150 WP_097306890.1 efflux RND transporter permease AcrB -
EW997_RS09175 (1784760) 1784760..1785134 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EW997_RS09180 (1785160) 1785160..1785378 + 219 WP_001291435.1 HHA domain-containing protein Toxin
EW997_RS09185 (1785550) 1785550..1786101 + 552 WP_000102568.1 maltose O-acetyltransferase -
EW997_RS09190 (1786217) 1786217..1786687 + 471 WP_000136192.1 YlaC family protein -
EW997_RS09195 (1786851) 1786851..1788401 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EW997_RS09200 (1788443) 1788443..1788796 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EW997_RS09210 (1789175) 1789175..1789486 + 312 WP_170867442.1 MGMT family protein -
EW997_RS09215 (1789517) 1789517..1790089 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T118971 WP_001291435.1 NZ_CP035879:1785160-1785378 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T118971 NZ_CP035879:1785160-1785378 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT118971 WP_000344800.1 NZ_CP035879:1784760-1785134 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT118971 NZ_CP035879:1784760-1785134 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References