Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3388263..3389107 Replicon chromosome
Accession NZ_CP035874
Organism Escherichia coli strain B2C

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag EW998_RS16410 Protein ID WP_000854686.1
Coordinates 3388263..3388646 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag EW998_RS16415 Protein ID WP_001285602.1
Coordinates 3388727..3389107 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW998_RS16380 (3384940) 3384940..3385644 + 705 WP_001241677.1 leucyl/phenylalanyl-tRNA--protein transferase -
EW998_RS16385 (3385929) 3385929..3386147 + 219 WP_001040187.1 translation initiation factor IF-1 -
EW998_RS16395 (3386637) 3386637..3387479 - 843 WP_032323406.1 DUF4942 domain-containing protein -
EW998_RS16400 (3387564) 3387564..3387761 - 198 WP_000839253.1 DUF957 domain-containing protein -
EW998_RS16405 (3387778) 3387778..3388266 - 489 WP_001054233.1 DUF5983 family protein -
EW998_RS16410 (3388263) 3388263..3388646 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
EW998_RS16415 (3388727) 3388727..3389107 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW998_RS16420 (3389118) 3389118..3389495 - 378 WP_000271247.1 hypothetical protein -
EW998_RS16425 (3389668) 3389668..3390780 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
EW998_RS16430 (3390848) 3390848..3391150 - 303 Protein_3216 hypothetical protein -
EW998_RS16435 (3391169) 3391169..3391390 - 222 WP_000692298.1 DUF987 domain-containing protein -
EW998_RS16440 (3391453) 3391453..3391929 - 477 WP_001186726.1 RadC family protein -
EW998_RS16445 (3391945) 3391945..3392430 - 486 WP_000214307.1 antirestriction protein -
EW998_RS16450 (3392522) 3392522..3393340 - 819 WP_001234726.1 DUF932 domain-containing protein -
EW998_RS16455 (3393440) 3393440..3393673 - 234 WP_001119717.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T118952 WP_000854686.1 NZ_CP035874:c3388646-3388263 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T118952 NZ_CP035874:c3388646-3388263 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT118952 WP_001285602.1 NZ_CP035874:c3389107-3388727 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT118952 NZ_CP035874:c3389107-3388727 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References