Detailed information of TA system TA118936

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 406156..406991
• Replicon: chromosome
• Accession: NZ_CP035874
• Organism: Escherichia coli strain B2C

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: EW998_RS01885
• Protein ID: WP_000854743.1
• Coordinates: 406156..406533 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: EW998_RS01890
• Protein ID: WP_001285298.1
• Coordinates: 406623..406991 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW998_RS01860 (401514)	401514..402437	-	924	WP_000535961.1	carboxylate/amino acid/amine transporter	-
EW998_RS01865 (402548)	402548..403732	-	1185	WP_001172882.1	sugar efflux transporter	-
EW998_RS25780 (404129)	404129..404290	-	162	Protein_350	virulence RhuM family protein	-
EW998_RS01870 (404527)	404527..405365	-	839	Protein_351	DUF4942 domain-containing protein	-
EW998_RS01875 (405462)	405462..405659	-	198	WP_000839275.1	DUF957 domain-containing protein	-
EW998_RS01880 (405671)	405671..406159	-	489	WP_000761693.1	DUF5983 family protein	-
EW998_RS01885 (406156)	406156..406533	-	378	WP_000854743.1	TA system toxin CbtA family protein	Toxin
EW998_RS01890 (406623)	406623..406991	-	369	WP_001285298.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EW998_RS01895 (407041)	407041..407685	-	645	WP_000086754.1	hypothetical protein	-
EW998_RS01900 (407704)	407704..407925	-	222	WP_000692307.1	DUF987 domain-containing protein	-
EW998_RS01905 (407988)	407988..408464	-	477	WP_001186774.1	RadC family protein	-
EW998_RS01910 (408479)	408479..408964	-	486	WP_000206659.1	antirestriction protein	-
EW998_RS01915 (409056)	409056..409877	-	822	WP_001706654.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14172.08 Da
• Isoelectric Point: 6.8519

>T118936 WP_000854743.1 NZ_CP035874:c406533-406156 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T118936 NZ_CP035874:c406533-406156 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13710.44 Da
• Isoelectric Point: 5.8799

>AT118936 WP_001285298.1 NZ_CP035874:c406991-406623 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Nucleotide

• Length: 369 bp

>AT118936 NZ_CP035874:c406991-406623 [Escherichia coli]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA