Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 57596..58143 | Replicon | plasmid pE275a_100 |
| Accession | NZ_CP035867 | ||
| Organism | Escherichia coli strain E275 a | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | EXE34_RS25650 | Protein ID | WP_249530679.1 |
| Coordinates | 57596..57874 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6G9U792 |
| Locus tag | EXE34_RS25655 | Protein ID | WP_000079935.1 |
| Coordinates | 57874..58143 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXE34_RS25605 (52813) | 52813..53058 | - | 246 | Protein_61 | IS630 family transposase | - |
| EXE34_RS25610 (53145) | 53145..53363 | + | 219 | Protein_62 | IS91 family transposase | - |
| EXE34_RS25615 (53552) | 53552..53653 | - | 102 | Protein_63 | methionyl-tRNA formyltransferase | - |
| EXE34_RS25620 (53668) | 53668..54177 | - | 510 | WP_000115001.1 | peptide deformylase | - |
| EXE34_RS25625 (54705) | 54705..55070 | + | 366 | WP_000124103.1 | hypothetical protein | - |
| EXE34_RS25630 (55070) | 55070..56257 | + | 1188 | Protein_66 | IS91 family transposase | - |
| EXE34_RS25635 (56575) | 56575..57057 | - | 483 | WP_033879534.1 | hypothetical protein | - |
| EXE34_RS25640 (57059) | 57059..57325 | - | 267 | WP_000215180.1 | hypothetical protein | - |
| EXE34_RS25645 (57326) | 57326..57550 | - | 225 | WP_033879533.1 | hypothetical protein | - |
| EXE34_RS25650 (57596) | 57596..57874 | - | 279 | WP_249530679.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| EXE34_RS25655 (57874) | 57874..58143 | - | 270 | WP_000079935.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| EXE34_RS25660 (59056) | 59056..59913 | - | 858 | WP_000130964.1 | incFII family plasmid replication initiator RepA | - |
| EXE34_RS26780 (59906) | 59906..59953 | - | 48 | WP_234812421.1 | hypothetical protein | - |
| EXE34_RS26785 (59944) | 59944..60177 | + | 234 | WP_231819095.1 | replication protein RepA | - |
| EXE34_RS25670 (60203) | 60203..60463 | - | 261 | WP_000083817.1 | replication regulatory protein RepA | - |
| EXE34_RS25675 (60747) | 60747..60896 | - | 150 | WP_001336447.1 | Hok/Gef family protein | - |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | - |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | - |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | - |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | - |
| EXE34_RS25680 (61245) | 61245..61427 | + | 183 | WP_001393357.1 | hypothetical protein | - |
| EXE34_RS25685 (61652) | 61652..62383 | - | 732 | WP_001071488.1 | type-F conjugative transfer system pilin acetylase TraX | - |
| EXE34_RS25690 (62380) | 62380..62946 | - | 567 | WP_074511253.1 | DUF2726 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | etpA / etpB | 1..100141 | 100141 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10747.40 Da Isoelectric Point: 8.4615
>T118905 WP_249530679.1 NZ_CP035867:c57874-57596 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGLPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGLPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T118905 NZ_CP035867:c57874-57596 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCAAGCCAGGACAGAAAGCGCATTCGTGAATACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCTGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATTCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATGCTGGCAAGCCAGGACAGAAAGCGCATTCGTGAATACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCTGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATTCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 10198.53 Da Isoelectric Point: 8.8735
>AT118905 WP_000079935.1 NZ_CP035867:c58143-57874 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLTHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLTHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT118905 NZ_CP035867:c58143-57874 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTACCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTACCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|