Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1999332..1999858 | Replicon | chromosome |
| Accession | NZ_CP035865 | ||
| Organism | Escherichia coli strain E275 a | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EXE34_RS09700 | Protein ID | WP_000323025.1 |
| Coordinates | 1999571..1999858 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EXE34_RS09695 | Protein ID | WP_000534858.1 |
| Coordinates | 1999332..1999571 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXE34_RS09665 (1994668) | 1994668..1995157 | + | 490 | Protein_1914 | class I SAM-dependent methyltransferase | - |
| EXE34_RS09675 (1995635) | 1995635..1996055 | + | 421 | Protein_1915 | hypothetical protein | - |
| EXE34_RS09680 (1996711) | 1996711..1997760 | + | 1050 | Protein_1916 | ISNCY family transposase | - |
| EXE34_RS26660 (1997881) | 1997881..1998030 | + | 150 | WP_011443592.1 | protein YdfW | - |
| EXE34_RS09685 (1998467) | 1998467..1998799 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| EXE34_RS09690 (1999002) | 1999002..1999307 | - | 306 | WP_071593935.1 | protein YdfV | - |
| EXE34_RS09695 (1999332) | 1999332..1999571 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EXE34_RS09700 (1999571) | 1999571..1999858 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EXE34_RS09705 (1999930) | 1999930..2000085 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EXE34_RS09710 (2000302) | 2000302..2000553 | + | 252 | WP_001463433.1 | protein Rem | - |
| EXE34_RS09715 (2000620) | 2000620..2000898 | + | 279 | WP_040091072.1 | hypothetical protein | - |
| EXE34_RS09720 (2000900) | 2000900..2001949 | + | 1050 | WP_016247238.1 | DUF968 domain-containing protein | - |
| EXE34_RS09725 (2001963) | 2001963..2002715 | + | 753 | WP_001047135.1 | antitermination protein | - |
| EXE34_RS09730 (2002993) | 2002993..2003082 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| EXE34_RS09735 (2003137) | 2003137..2003349 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EXE34_RS09740 (2003650) | 2003650..2003865 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EXE34_RS09745 (2004229) | 2004229..2004399 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| EXE34_RS09750 (2004619) | 2004619..2004834 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1971729..2035264 | 63535 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T118890 WP_000323025.1 NZ_CP035865:1999571-1999858 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T118890 NZ_CP035865:1999571-1999858 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT118890 WP_000534858.1 NZ_CP035865:1999332-1999571 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT118890 NZ_CP035865:1999332-1999571 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|