Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4197138..4197733 Replicon chromosome
Accession NZ_CP035855
Organism Escherichia coli TW11681

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag EXE31_RS20375 Protein ID WP_000239579.1
Coordinates 4197383..4197733 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag EXE31_RS20370 Protein ID WP_001223208.1
Coordinates 4197138..4197389 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXE31_RS20360 (4192803) 4192803..4196582 + 3780 WP_000060907.1 autotransporter assembly complex protein TamB -
EXE31_RS20365 (4196585) 4196585..4196926 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
EXE31_RS20370 (4197138) 4197138..4197389 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EXE31_RS20375 (4197383) 4197383..4197733 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
EXE31_RS20380 (4197810) 4197810..4198340 - 531 WP_000055072.1 inorganic diphosphatase -
EXE31_RS20385 (4198650) 4198650..4199606 + 957 WP_000265941.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EXE31_RS20390 (4199746) 4199746..4201248 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
EXE31_RS20395 (4201262) 4201262..4202284 + 1023 WP_001295197.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T118842 WP_000239579.1 NZ_CP035855:4197383-4197733 [Escherichia coli TW11681]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T118842 NZ_CP035855:4197383-4197733 [Escherichia coli TW11681]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT118842 WP_001223208.1 NZ_CP035855:4197138-4197389 [Escherichia coli TW11681]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT118842 NZ_CP035855:4197138-4197389 [Escherichia coli TW11681]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References