Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1212116..1212642 Replicon chromosome
Accession NZ_CP035855
Organism Escherichia coli TW11681

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EXE31_RS06015 Protein ID WP_000323025.1
Coordinates 1212116..1212403 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EXE31_RS06020 Protein ID WP_000534858.1
Coordinates 1212403..1212642 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXE31_RS05965 (1207140) 1207140..1207355 - 216 WP_000839590.1 phage lysis protein EssD -
EXE31_RS05970 (1207575) 1207575..1207745 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
EXE31_RS05975 (1208109) 1208109..1208324 - 216 WP_000066484.1 cold shock-like protein CspB -
EXE31_RS05980 (1208625) 1208625..1208837 + 213 WP_000087756.1 cold shock-like protein CspF -
EXE31_RS05985 (1208892) 1208892..1208981 + 90 WP_120795389.1 hypothetical protein -
EXE31_RS05990 (1209259) 1209259..1210011 - 753 WP_001047135.1 antitermination protein -
EXE31_RS05995 (1210025) 1210025..1211074 - 1050 WP_001265200.1 DUF968 domain-containing protein -
EXE31_RS06000 (1211076) 1211076..1211354 - 279 WP_012304870.1 hypothetical protein -
EXE31_RS06005 (1211421) 1211421..1211672 - 252 WP_000980994.1 protein Rem -
EXE31_RS06010 (1211889) 1211889..1212044 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EXE31_RS06015 (1212116) 1212116..1212403 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EXE31_RS06020 (1212403) 1212403..1212642 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EXE31_RS06025 (1212667) 1212667..1212876 + 210 Protein_1182 hypothetical protein -
EXE31_RS06030 (1212875) 1212875..1212946 - 72 Protein_1183 transcriptional regulator -
EXE31_RS06035 (1212998) 1212998..1214211 + 1214 WP_164544915.1 IS3 family transposase -
EXE31_RS06040 (1214254) 1214254..1214316 - 63 Protein_1185 dicB transcriptional regulator DicC -
EXE31_RS06045 (1214400) 1214400..1214807 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
EXE31_RS06050 (1214974) 1214974..1215129 + 156 WP_000379575.1 DUF1391 family protein -
EXE31_RS06055 (1215131) 1215131..1215706 + 576 WP_000344953.1 hypothetical protein -
EXE31_RS06060 (1216193) 1216193..1216381 + 189 WP_000854559.1 cell division inhibition protein DicB -
EXE31_RS06065 (1216378) 1216378..1216569 + 192 WP_001083278.1 lysis protein YdfD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1191041..1233789 42748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T118826 WP_000323025.1 NZ_CP035855:c1212403-1212116 [Escherichia coli TW11681]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T118826 NZ_CP035855:c1212403-1212116 [Escherichia coli TW11681]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT118826 WP_000534858.1 NZ_CP035855:c1212642-1212403 [Escherichia coli TW11681]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT118826 NZ_CP035855:c1212642-1212403 [Escherichia coli TW11681]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References