Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 43822..44369 | Replicon | plasmid pTW10598_63 |
| Accession | NZ_CP035848 | ||
| Organism | Escherichia coli strain TW10598 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G7QEJ9 |
| Locus tag | EXA01_RS24900 | Protein ID | WP_001384452.1 |
| Coordinates | 44091..44369 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q4FIL6 |
| Locus tag | EXA01_RS24895 | Protein ID | WP_000079945.1 |
| Coordinates | 43822..44091 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXA01_RS24855 (39445) | 39445..39657 | + | 213 | WP_001301409.1 | ANR family transcriptional regulator | - |
| EXA01_RS24860 (39903) | 39903..40364 | + | 462 | WP_001233850.1 | thermonuclease family protein | - |
| EXA01_RS24865 (40410) | 40410..40619 | + | 210 | WP_001353639.1 | Hha/YmoA family nucleoid-associated regulatory protein | - |
| EXA01_RS24870 (40657) | 40657..41247 | + | 591 | WP_000766829.1 | DUF2726 domain-containing protein | - |
| EXA01_RS24875 (41487) | 41487..41747 | + | 261 | WP_000078109.1 | replication regulatory protein RepA | - |
| EXA01_RS25710 (41783) | 41783..42019 | - | 237 | WP_244574115.1 | replication protein RepA | - |
| EXA01_RS25715 (42010) | 42010..42057 | + | 48 | WP_077822033.1 | hypothetical protein | - |
| EXA01_RS24885 (42050) | 42050..42907 | + | 858 | WP_000130963.1 | incFII family plasmid replication initiator RepA | - |
| EXA01_RS24890 (43609) | 43609..43749 | + | 141 | WP_000829596.1 | hypothetical protein | - |
| EXA01_RS24895 (43822) | 43822..44091 | + | 270 | WP_000079945.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| EXA01_RS24900 (44091) | 44091..44369 | + | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| EXA01_RS24905 (44441) | 44441..44619 | + | 179 | Protein_60 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| EXA01_RS24910 (44690) | 44690..45571 | + | 882 | WP_000005460.1 | hypothetical protein | - |
| EXA01_RS24915 (45506) | 45506..45925 | - | 420 | WP_086405430.1 | hypothetical protein | - |
| EXA01_RS24920 (46034) | 46034..46384 | - | 351 | WP_001414994.1 | plasmid partitioning/stability family protein | - |
| EXA01_RS24925 (46387) | 46387..47349 | - | 963 | WP_000959884.1 | plasmid segregation protein ParM | - |
| EXA01_RS24930 (47520) | 47520..47789 | + | 270 | WP_072126982.1 | hypothetical protein | - |
| EXA01_RS24935 (47884) | 47884..48762 | + | 879 | WP_000545759.1 | DUF1281 domain-containing protein | - |
| EXA01_RS24940 (48753) | 48753..48938 | + | 186 | Protein_67 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(B) | - | 1..63103 | 63103 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10762.38 Da Isoelectric Point: 8.4615
>T118789 WP_001384452.1 NZ_CP035848:44091-44369 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T118789 NZ_CP035848:44091-44369 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 10180.52 Da Isoelectric Point: 8.8735
>AT118789 WP_000079945.1 NZ_CP035848:43822-44091 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT118789 NZ_CP035848:43822-44091 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTTCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTTCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CL36 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q4FIL6 |