Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2726721..2727556 Replicon chromosome
Accession NZ_CP035846
Organism Escherichia coli strain TW10598

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EXA01_RS13180 Protein ID WP_000854743.1
Coordinates 2726721..2727098 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EXA01_RS13185 Protein ID WP_001285298.1
Coordinates 2727188..2727556 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA01_RS13155 (2722079) 2722079..2723002 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
EXA01_RS13160 (2723113) 2723113..2724297 - 1185 WP_001172882.1 sugar efflux transporter -
EXA01_RS25540 (2724694) 2724694..2724855 - 162 Protein_2574 virulence RhuM family protein -
EXA01_RS13165 (2725092) 2725092..2725930 - 839 Protein_2575 DUF4942 domain-containing protein -
EXA01_RS13170 (2726027) 2726027..2726224 - 198 WP_000839275.1 DUF957 domain-containing protein -
EXA01_RS13175 (2726236) 2726236..2726724 - 489 WP_000761693.1 DUF5983 family protein -
EXA01_RS13180 (2726721) 2726721..2727098 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
EXA01_RS13185 (2727188) 2727188..2727556 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EXA01_RS13190 (2727606) 2727606..2728250 - 645 WP_000086754.1 hypothetical protein -
EXA01_RS13195 (2728269) 2728269..2728490 - 222 WP_000692307.1 DUF987 domain-containing protein -
EXA01_RS13200 (2728553) 2728553..2729029 - 477 WP_001186774.1 RadC family protein -
EXA01_RS13205 (2729044) 2729044..2729529 - 486 WP_000206659.1 antirestriction protein -
EXA01_RS13210 (2729621) 2729621..2729779 - 159 Protein_2584 DUF945 domain-containing protein -
EXA01_RS13215 (2729809) 2729809..2731380 - 1572 WP_000381401.1 IS66 family transposase -
EXA01_RS13220 (2731400) 2731400..2731747 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
EXA01_RS13225 (2731747) 2731747..2732424 - 678 WP_001704819.1 IS66-like element accessory protein TnpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T118773 WP_000854743.1 NZ_CP035846:c2727098-2726721 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T118773 NZ_CP035846:c2727098-2726721 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT118773 WP_001285298.1 NZ_CP035846:c2727556-2727188 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT118773 NZ_CP035846:c2727556-2727188 [Escherichia coli]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References