Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1417446..1418064 Replicon chromosome
Accession NZ_CP035846
Organism Escherichia coli strain TW10598

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EXA01_RS06945 Protein ID WP_001291435.1
Coordinates 1417846..1418064 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag EXA01_RS06940 Protein ID WP_000344789.1
Coordinates 1417446..1417820 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA01_RS06930 (1412535) 1412535..1413728 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EXA01_RS06935 (1413751) 1413751..1416900 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
EXA01_RS06940 (1417446) 1417446..1417820 + 375 WP_000344789.1 Hha toxicity modulator TomB Antitoxin
EXA01_RS06945 (1417846) 1417846..1418064 + 219 WP_001291435.1 HHA domain-containing protein Toxin
EXA01_RS06950 (1418236) 1418236..1418787 + 552 WP_000102564.1 maltose O-acetyltransferase -
EXA01_RS06955 (1418903) 1418903..1419373 + 471 WP_000136192.1 YlaC family protein -
EXA01_RS06960 (1419537) 1419537..1421087 + 1551 WP_001529523.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EXA01_RS06965 (1421129) 1421129..1421482 - 354 WP_000878143.1 DUF1428 domain-containing protein -
EXA01_RS06975 (1421861) 1421861..1422172 + 312 WP_000409911.1 MGMT family protein -
EXA01_RS06980 (1422203) 1422203..1422775 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T118770 WP_001291435.1 NZ_CP035846:1417846-1418064 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T118770 NZ_CP035846:1417846-1418064 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14569.44 Da        Isoelectric Point: 4.7395

>AT118770 WP_000344789.1 NZ_CP035846:1417446-1417820 [Escherichia coli]
MDEYSPKRHDIAQLKFLCEILYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT118770 NZ_CP035846:1417446-1417820 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAATCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References