Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 786382..786908 | Replicon | chromosome |
| Accession | NZ_CP035836 | ||
| Organism | Escherichia coli strain WS1933D | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EXA03_RS04055 | Protein ID | WP_000323025.1 |
| Coordinates | 786382..786669 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EXA03_RS04060 | Protein ID | WP_000534858.1 |
| Coordinates | 786669..786908 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXA03_RS04005 (781406) | 781406..781621 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| EXA03_RS04010 (781841) | 781841..782011 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| EXA03_RS04015 (782375) | 782375..782590 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EXA03_RS04020 (782891) | 782891..783103 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EXA03_RS04025 (783158) | 783158..783247 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| EXA03_RS04030 (783525) | 783525..784277 | - | 753 | WP_001047135.1 | antitermination protein | - |
| EXA03_RS04035 (784291) | 784291..785340 | - | 1050 | WP_001265200.1 | DUF968 domain-containing protein | - |
| EXA03_RS04040 (785342) | 785342..785620 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| EXA03_RS04045 (785687) | 785687..785938 | - | 252 | WP_000980994.1 | protein Rem | - |
| EXA03_RS04050 (786155) | 786155..786310 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EXA03_RS04055 (786382) | 786382..786669 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EXA03_RS04060 (786669) | 786669..786908 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EXA03_RS04065 (786933) | 786933..787142 | + | 210 | Protein_804 | hypothetical protein | - |
| EXA03_RS04070 (787141) | 787141..787269 | - | 129 | Protein_805 | dicB transcriptional regulator DicC | - |
| EXA03_RS04075 (787353) | 787353..787760 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| EXA03_RS04080 (787927) | 787927..788082 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| EXA03_RS04085 (788084) | 788084..788659 | + | 576 | WP_000344953.1 | hypothetical protein | - |
| EXA03_RS04090 (789146) | 789146..789334 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| EXA03_RS04095 (789331) | 789331..789522 | + | 192 | WP_001083278.1 | lysis protein YdfD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 765307..794759 | 29452 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T118702 WP_000323025.1 NZ_CP035836:c786669-786382 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T118702 NZ_CP035836:c786669-786382 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT118702 WP_000534858.1 NZ_CP035836:c786908-786669 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT118702 NZ_CP035836:c786908-786669 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|