Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3162218..3163062 Replicon chromosome
Accession NZ_CP035832
Organism Escherichia coli strain 025542-1

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag EXA04_RS15680 Protein ID WP_000854686.1
Coordinates 3162218..3162601 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag EXA04_RS15685 Protein ID WP_001285602.1
Coordinates 3162682..3163062 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA04_RS15640 (3157220) 3157220..3157711 - 492 WP_001297187.1 DUF1097 domain-containing protein -
EXA04_RS15645 (3157813) 3157813..3158367 - 555 WP_001001902.1 molecular chaperone YcdY -
EXA04_RS15650 (3158391) 3158391..3159128 - 738 WP_000283664.1 zinc-binding phosphatase -
EXA04_RS15655 (3159183) 3159183..3160121 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
EXA04_RS15665 (3160592) 3160592..3161434 - 843 WP_001696893.1 DUF4942 domain-containing protein -
EXA04_RS15670 (3161519) 3161519..3161716 - 198 WP_000839253.1 DUF957 domain-containing protein -
EXA04_RS15675 (3161733) 3161733..3162221 - 489 WP_001696892.1 DUF5983 family protein -
EXA04_RS15680 (3162218) 3162218..3162601 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
EXA04_RS15685 (3162682) 3162682..3163062 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EXA04_RS15690 (3163073) 3163073..3163756 - 684 WP_001696891.1 hypothetical protein -
EXA04_RS15695 (3163775) 3163775..3163996 - 222 WP_001696890.1 DUF987 domain-containing protein -
EXA04_RS15700 (3164059) 3164059..3164535 - 477 WP_001186726.1 RadC family protein -
EXA04_RS15705 (3164551) 3164551..3165036 - 486 WP_001697217.1 antirestriction protein -
EXA04_RS15710 (3165128) 3165128..3165946 - 819 WP_001697216.1 DUF932 domain-containing protein -
EXA04_RS15715 (3166046) 3166046..3166279 - 234 WP_001119719.1 DUF905 family protein -
EXA04_RS15720 (3166358) 3166358..3166812 - 455 Protein_3088 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgC / csgA / csgB / csgD / csgE / csgF / csgG 3152715..3175772 23057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T118692 WP_000854686.1 NZ_CP035832:c3162601-3162218 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T118692 NZ_CP035832:c3162601-3162218 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT118692 WP_001285602.1 NZ_CP035832:c3163062-3162682 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT118692 NZ_CP035832:c3163062-3162682 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References