Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 69359..70191 | Replicon | chromosome |
| Accession | NZ_CP035832 | ||
| Organism | Escherichia coli strain 025542-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | E3PN67 |
| Locus tag | EXA04_RS00365 | Protein ID | WP_000854775.1 |
| Coordinates | 69359..69733 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A426P7N5 |
| Locus tag | EXA04_RS00370 | Protein ID | WP_001285645.1 |
| Coordinates | 69823..70191 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXA04_RS00335 (64721) | 64721..65644 | - | 924 | WP_000535960.1 | carboxylate/amino acid/amine transporter | - |
| EXA04_RS00340 (65755) | 65755..66939 | - | 1185 | WP_216317210.1 | sugar efflux transporter | - |
| EXA04_RS00345 (67369) | 67369..67497 | - | 129 | Protein_67 | virulence RhuM family protein | - |
| EXA04_RS00350 (67735) | 67735..68577 | - | 843 | WP_001274548.1 | DUF4942 domain-containing protein | - |
| EXA04_RS00355 (68662) | 68662..68859 | - | 198 | WP_000772035.1 | DUF957 domain-containing protein | - |
| EXA04_RS00360 (68871) | 68871..69362 | - | 492 | WP_000976825.1 | DUF5983 family protein | - |
| EXA04_RS00365 (69359) | 69359..69733 | - | 375 | WP_000854775.1 | TA system toxin CbtA family protein | Toxin |
| EXA04_RS00370 (69823) | 69823..70191 | - | 369 | WP_001285645.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EXA04_RS00375 (70354) | 70354..70575 | - | 222 | WP_000692303.1 | DUF987 domain-containing protein | - |
| EXA04_RS00380 (70644) | 70644..71120 | - | 477 | WP_001186201.1 | RadC family protein | - |
| EXA04_RS00385 (71136) | 71136..71621 | - | 486 | WP_000213721.1 | antirestriction protein | - |
| EXA04_RS00390 (71713) | 71713..72531 | - | 819 | WP_001175173.1 | DUF932 domain-containing protein | - |
| EXA04_RS00395 (72621) | 72621..72854 | - | 234 | WP_001278284.1 | DUF905 family protein | - |
| EXA04_RS00400 (72860) | 72860..73537 | - | 678 | WP_001097566.1 | hypothetical protein | - |
| EXA04_RS00405 (73688) | 73688..74368 | - | 681 | WP_001282911.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13965.02 Da Isoelectric Point: 8.2830
>T118675 WP_000854775.1 NZ_CP035832:c69733-69359 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T118675 NZ_CP035832:c69733-69359 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13678.37 Da Isoelectric Point: 5.4492
>AT118675 WP_001285645.1 NZ_CP035832:c70191-69823 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT118675 NZ_CP035832:c70191-69823 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | E3PN67 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A426P7N5 |