Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 41585..42144 Replicon plasmid p67_75
Accession NZ_CP035830
Organism Escherichia coli strain 67-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EXA05_RS26390 Protein ID WP_000421261.1
Coordinates 41869..42144 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EXA05_RS26385 Protein ID WP_001297026.1
Coordinates 41585..41869 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA05_RS26365 (36995) 36995..37141 - 147 WP_235777688.1 PilI type IV pilus biogenesis protein -
EXA05_RS26370 (37496) 37496..38161 - 666 WP_000154140.1 hypothetical protein -
EXA05_RS26375 (38302) 38302..38808 - 507 WP_001317510.1 transcription termination/antitermination NusG family protein -
EXA05_RS26380 (39646) 39646..40677 + 1032 WP_000907882.1 plasmid replication initiator RepA -
EXA05_RS26385 (41585) 41585..41869 + 285 WP_001297026.1 ribbon-helix-helix domain-containing protein Antitoxin
EXA05_RS26390 (41869) 41869..42144 + 276 WP_000421261.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EXA05_RS26395 (42250) 42250..42453 + 204 Protein_45 hypothetical protein -
EXA05_RS26400 (42722) 42722..42988 - 267 WP_000627831.1 hypothetical protein -
EXA05_RS26405 (43126) 43126..43728 - 603 WP_000517694.1 ProQ/FINO family protein -
EXA05_RS26410 (44082) 44082..45428 + 1347 WP_001132022.1 protein YagA -
EXA05_RS26415 (45947) 45947..46249 - 303 WP_001245884.1 hypothetical protein -
EXA05_RS26420 (46246) 46246..46872 - 627 WP_000587689.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..75047 75047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10735.42 Da        Isoelectric Point: 9.9324

>T118670 WP_000421261.1 NZ_CP035830:41869-42144 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEVRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T118670 NZ_CP035830:41869-42144 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAGTCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.95 Da        Isoelectric Point: 5.6558

>AT118670 WP_001297026.1 NZ_CP035830:41585-41869 [Escherichia coli]
MQMKNNTVQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT118670 NZ_CP035830:41585-41869 [Escherichia coli]
ATGCAAATGAAAAACAATACCGTACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTCATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References