Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1241719..1242554 | Replicon | chromosome |
| Accession | NZ_CP035826 | ||
| Organism | Escherichia coli strain 67-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1V1GYU4 |
| Locus tag | EXA05_RS05980 | Protein ID | WP_000854719.1 |
| Coordinates | 1242177..1242554 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | EXA05_RS05975 | Protein ID | WP_001285113.1 |
| Coordinates | 1241719..1242087 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXA05_RS05935 (1236835) | 1236835..1237719 | + | 885 | WP_000010398.1 | 50S ribosome-binding GTPase | - |
| EXA05_RS05940 (1237838) | 1237838..1238515 | + | 678 | WP_001097369.1 | hypothetical protein | - |
| EXA05_RS05945 (1238521) | 1238521..1238754 | + | 234 | WP_001278282.1 | DUF905 family protein | - |
| EXA05_RS05950 (1238844) | 1238844..1239662 | + | 819 | WP_001175145.1 | DUF932 domain-containing protein | - |
| EXA05_RS05955 (1239739) | 1239739..1240224 | + | 486 | WP_000213705.1 | antirestriction protein | - |
| EXA05_RS05960 (1240240) | 1240240..1240716 | + | 477 | WP_001186715.1 | RadC family protein | - |
| EXA05_RS05965 (1240785) | 1240785..1241006 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| EXA05_RS05970 (1241025) | 1241025..1241669 | + | 645 | WP_000086770.1 | hypothetical protein | - |
| EXA05_RS05975 (1241719) | 1241719..1242087 | + | 369 | WP_001285113.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EXA05_RS05980 (1242177) | 1242177..1242554 | + | 378 | WP_000854719.1 | TA system toxin CbtA family protein | Toxin |
| EXA05_RS05985 (1242551) | 1242551..1243039 | + | 489 | WP_000761679.1 | DUF5983 family protein | - |
| EXA05_RS05990 (1243057) | 1243057..1243254 | + | 198 | WP_000839266.1 | DUF957 domain-containing protein | - |
| EXA05_RS05995 (1243339) | 1243339..1244184 | + | 846 | WP_001440175.1 | DUF4942 domain-containing protein | - |
| EXA05_RS06000 (1244253) | 1244253..1244648 | + | 396 | WP_000208386.1 | DUF6088 family protein | - |
| EXA05_RS06005 (1244641) | 1244641..1245588 | + | 948 | WP_001440173.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| EXA05_RS06010 (1245943) | 1245943..1246479 | - | 537 | WP_000942792.1 | GspM family type II secretion system protein YghD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | sul1 / qacE / ere(A) / dfrA5 / catA1 | - | 1173309..1245588 | 72279 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14059.10 Da Isoelectric Point: 8.2904
>T118650 WP_000854719.1 NZ_CP035826:1242177-1242554 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T118650 NZ_CP035826:1242177-1242554 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13693.33 Da Isoelectric Point: 5.4970
>AT118650 WP_001285113.1 NZ_CP035826:1241719-1242087 [Escherichia coli]
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT
Download Length: 369 bp
>AT118650 NZ_CP035826:1241719-1242087 [Escherichia coli]
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|