Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 833215..834047 Replicon chromosome
Accession NZ_CP035826
Organism Escherichia coli strain 67-1

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag EXA05_RS03945 Protein ID WP_001094452.1
Coordinates 833673..834047 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7I8Z144
Locus tag EXA05_RS03940 Protein ID WP_016255729.1
Coordinates 833215..833583 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA05_RS03915 (830637) 830637..830870 + 234 WP_001117567.1 DUF905 family protein -
EXA05_RS03920 (830970) 830970..831788 + 819 WP_001234594.1 DUF932 domain-containing protein -
EXA05_RS03925 (831880) 831880..832365 + 486 WP_000213708.1 antirestriction protein -
EXA05_RS03930 (832380) 832380..832856 + 477 WP_001484796.1 RadC family protein -
EXA05_RS03935 (832919) 832919..833140 + 222 WP_000692315.1 DUF987 domain-containing protein -
EXA05_RS03940 (833215) 833215..833583 + 369 WP_016255729.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EXA05_RS03945 (833673) 833673..834047 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
EXA05_RS03950 (834044) 834044..834535 + 492 WP_000977086.1 DUF5983 family protein -
EXA05_RS03955 (834546) 834546..834743 + 198 WP_000839264.1 DUF957 domain-containing protein -
EXA05_RS03960 (834828) 834828..835673 + 846 WP_001280506.1 DUF4942 domain-containing protein -
EXA05_RS03970 (836407) 836407..838658 + 2252 Protein_777 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T118647 WP_001094452.1 NZ_CP035826:833673-834047 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T118647 NZ_CP035826:833673-834047 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCTCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCACCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13750.53 Da        Isoelectric Point: 6.7395

>AT118647 WP_016255729.1 NZ_CP035826:833215-833583 [Escherichia coli]
VSDTLHETTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT118647 NZ_CP035826:833215-833583 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGA
GAACTGAATCCCCGTCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7I8Z144

References