Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1095297..1095823 | Replicon | chromosome |
| Accession | NZ_CP035822 | ||
| Organism | Escherichia coli strain WS4437A-1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EXA06_RS05450 | Protein ID | WP_000323025.1 |
| Coordinates | 1095297..1095584 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EXA06_RS05455 | Protein ID | WP_000534858.1 |
| Coordinates | 1095584..1095823 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXA06_RS05400 (1090321) | 1090321..1090536 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| EXA06_RS05405 (1090756) | 1090756..1090926 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| EXA06_RS05410 (1091290) | 1091290..1091505 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EXA06_RS05415 (1091806) | 1091806..1092018 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EXA06_RS05420 (1092073) | 1092073..1092162 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| EXA06_RS05425 (1092440) | 1092440..1093192 | - | 753 | WP_001047135.1 | antitermination protein | - |
| EXA06_RS05430 (1093206) | 1093206..1094255 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| EXA06_RS05435 (1094257) | 1094257..1094535 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| EXA06_RS05440 (1094602) | 1094602..1094853 | - | 252 | WP_000980994.1 | protein Rem | - |
| EXA06_RS05445 (1095070) | 1095070..1095225 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EXA06_RS05450 (1095297) | 1095297..1095584 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EXA06_RS05455 (1095584) | 1095584..1095823 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EXA06_RS05460 (1095848) | 1095848..1096153 | + | 306 | WP_001326990.1 | protein YdfV | - |
| EXA06_RS05465 (1096356) | 1096356..1096688 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| EXA06_RS24525 (1097125) | 1097125..1097274 | - | 150 | WP_011443592.1 | protein YdfW | - |
| EXA06_RS05470 (1097395) | 1097395..1098417 | - | 1023 | Protein_1071 | ISNCY family transposase | - |
| EXA06_RS05475 (1099207) | 1099207..1099494 | - | 288 | Protein_1072 | hypothetical protein | - |
| EXA06_RS05480 (1099972) | 1099972..1100461 | - | 490 | Protein_1073 | class I SAM-dependent methyltransferase | - |
| EXA06_RS05485 (1100458) | 1100458..1100709 | - | 252 | Protein_1074 | DUF977 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1075688..1108528 | 32840 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T118625 WP_000323025.1 NZ_CP035822:c1095584-1095297 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T118625 NZ_CP035822:c1095584-1095297 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT118625 WP_000534858.1 NZ_CP035822:c1095823-1095584 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT118625 NZ_CP035822:c1095823-1095584 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|